About the Authors

Kimberly Stegmaier

Affiliations Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America , The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Jenny S Wong

Affiliations Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America , Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Kenneth N Ross

Affiliation The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Kwan T Chow

Affiliation Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America

David Peck

Affiliation The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Renee D Wright

Affiliation Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America

Stephen L Lessnick

Affiliation The Center for Children, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America

Andrew L Kung

Affiliation Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America

Todd R Golub

To whom correspondence should be addressed. E-mail: golub@broad.mit.edu

Affiliations Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America , The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America , Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KS and TRG designed the study and wrote the manuscript. KS, JSW, and KTC performed the research and analyzed data. KNR performed the computational analyses. RDW and ALK performed and analyzed the xenograft experiments. SLL developed the EWS/FLI directed RNAi system. DP contributed to technical development of the GE-HTS platform.