About the Authors
- Romulo M Brena
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Affiliations Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, United States of America , Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Cancer Genetics, The Ohio State University, Columbus, Ohio, United States of America
- Carl Morrison
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Affiliation Department of Pathology, The Ohio State University, Columbus, Ohio, United States of America
- Sandya Liyanarachchi
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Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Cancer Genetics, The Ohio State University, Columbus, Ohio, United States of America
- David Jarjoura
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Affiliation Division of Biostatistics, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio, United States of America
- Ramana V Davuluri
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Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Cancer Genetics, The Ohio State University, Columbus, Ohio, United States of America
- Gregory A Otterson
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Affiliation Department of Internal Medicine, Division of Hematology and Oncology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio, United States of America
- David Reisman
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Affiliation Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, Michigan, United States of America
- Selina Glaros
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Affiliation Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, Michigan, United States of America
- Laura J Rush
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Affiliation Department of Veterinary Biosciences and the Comprehensive Cancer Center, The Ohio State University Columbus, Ohio, United States of America
- Christoph Plass
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*To whom correspondence should be addressed. E-mail: christoph.plass@osumc.edu
Affiliation Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Cancer Genetics, The Ohio State University, Columbus, Ohio, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
RMB, SL, and CP designed the study. RMB, CM, SL, DJ, RVD, and CP analyzed the data. RMB and CM collected data or did experiments for the study. DJ critiqued drafts and performed reanalysis and analysis of new data to address concerns. GAO reviewed the primary data and the clinical data and provided clinical context regarding lung cancer to the OLIG methylation status. DR built two lung cancer tissue microarrays and collected the clinical follow-up data for ∼200 lung cancer cases. LJR contributed to data interpretation. RMB, CM, SL, DJ, RVD, GAO, DR, SG, LJR, and CP contributed to writing the paper.