About the Authors

Patricia C Galipeau

Contributed equally to this work with: Patricia C Galipeau, Xiaohong Li

To whom correspondence should be addressed. E-mail: pgal@fhcrc.org

Affiliations Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America , Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Xiaohong Li

Contributed equally to this work with: Patricia C Galipeau, Xiaohong Li

Affiliation Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Patricia L Blount

Affiliations Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America , Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America , Department of Medicine, University of Washington, Seattle, Washington, United States of America

Carlo C Maley

Affiliation Cellular and Molecular Oncogenesis Program, Wistar Institute, Philadelphia, Pennsylvania, United States of America

Carissa A Sanchez

Affiliations Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America , Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Robert D Odze

Affiliation Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Kamran Ayub

Affiliation Department of Gastroenterology, Virginia Mason Medical Center, Seattle, Washington, United States of America

Peter S Rabinovitch

Affiliations Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America , Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America , Department of Pathology, University of Washington, Seattle, Washington, United States of America

Thomas L Vaughan

Affiliations Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America , Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

Brian J Reid

Affiliations Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America , Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America , Department of Medicine, University of Washington, Seattle, Washington, United States of America , Genome Sciences, University of Washington, Seattle, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PCG, PLB, CAS, TLV, and BJR contributed to conception and design of the study. PCG, PLB, CAS, KA, TLV, and BJR collected data or did experiments for the study. PCG, XL, CCM, CAS, RDO, PSR, TLV, and BJR contributed to analysis and interpretation of the data. PLB and BJR enrolled patients. PCG, XL, PLB, CCM, CAS, RDO, KA, PSR, TLV, and BJR contributed to drafting the article or revising it critically. All authors approved the final accepted version of the manuscript.