About the Authors

Arthur Y Kim

Contributed equally to this work with: Arthur Y Kim, Julian Schulze zur Wiesch

To whom correspondence should be addressed. E-mail: akim1@partners.org

Affiliation Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Julian Schulze zur Wiesch

Contributed equally to this work with: Arthur Y Kim, Julian Schulze zur Wiesch

Affiliations Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America , Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Thomas Kuntzen

Affiliation Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Joerg Timm

Affiliation Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Daniel E Kaufmann

Affiliation Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Jared E Duncan

Affiliation Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Andrea M Jones

Affiliation Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Alysse G Wurcel

Affiliation Lemuel Shattuck Hospital, Jamaica Plain, Massachusetts, United States of America

Benjamin T Davis

Affiliation Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Rajesh T Gandhi

Affiliation Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Gregory K Robbins

Affiliation Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Todd M Allen

Affiliation Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Raymond T Chung

Affiliation Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Georg M Lauer

Affiliation Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Bruce D Walker

Affiliations Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America , Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AYK, JSzW, GML, and BDW designed the study. AYK, JSzW, TMA, GML, and BDW analyzed the data. AYK, JSzW, AGW, BTD, RTG, GKR, and RTC enrolled patients. AYK, JSzW, TK, JT, DEK, AMJ, BTD, RTG, GKR, TMA, RTC, GML, and BDW contributed to writing the paper. AYK, JSzW, AMJ, and JED performed the tissue culture work, including but not limited to: blood processing, cell culture, lymphoproliferation assays, elispot analysis, flow cytometry, maintaining cell lines, tetramer analysis, and DNA extractions. JT contributed to the sample processing, lymphoproliferation assays, Elispot assays, and cell culture work. TK and JT designed additional experiments to try to amplify virus from time points without detectable plasma viremia. BTD, RTG, and GKR identified patients with recurrent/relapsed HCV from the Infectious Disease Clinic at Massachusetts General Hospital and in collecting clinical data.