About the Authors

Jeffrey T.-J Huang

Contributed equally to this work with: Jeffrey T.-J Huang, F. Markus Leweke

Affiliation Institute of Biotechnology, University of Cambridge, Cambridge, United Kingdom

F. Markus Leweke

Contributed equally to this work with: Jeffrey T.-J Huang, F. Markus Leweke

Affiliation Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany

David Oxley

Affiliation Proteomics Research Group, Babraham Institute, Cambridge, United Kingdom

Lan Wang

Affiliation Institute of Biotechnology, University of Cambridge, Cambridge, United Kingdom

Nathan Harris

Affiliation Ciphergen Biosystems Ltd., Surrey Research Park, Guildford, Surrey, United Kingdom

Dagmar Koethe

Affiliation Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany

Christoph W Gerth

Affiliation Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany

Brit M Nolden

Affiliation Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany

Sonja Gross

Affiliation Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany

Daniela Schreiber

Affiliation Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany

Benjamin Reed

Affiliation Ciphergen Biosystems Ltd., Surrey Research Park, Guildford, Surrey, United Kingdom

Sabine Bahn

To whom correspondence should be addressed. E-mail: sb209@cam.ac.uk

Affiliation Institute of Biotechnology, University of Cambridge, Cambridge, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SB initiated and conceptualized the study. JTJH, FML, and SB designed the study. JTJH, FML, and LW analyzed the data. FML, DK, CWG, BMN, SG, and DS enrolled patients. JTJH, FML, and SB contributed to writing the paper. JTJH, FML, DO, LW, NH, DK, CWG, and SG collected data or carried out experiments for the study. DO performed the ESI-MS/MS and data analyses that identified the VGF peptide and the transthyretin. NH and BR helped design the initial pilot studies and collected some data from the experiments, as well as providing technical assistance and input regarding the identification of the proteins described in this paper. BR also coordinated all collaborative interactions with Ciphergen Biosystems.