About the Authors

David L Boyle

Affiliation Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, California, United States of America

Toni L Jones

Affiliation Department of Anesthesiology, University of California San Diego School of Medicine, La Jolla, California, United States of America

Deepa Hammaker

Affiliation Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, California, United States of America

Camille I Svensson

Affiliation Department of Anesthesiology, University of California San Diego School of Medicine, La Jolla, California, United States of America

Sanna Rosengren

Affiliation Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, California, United States of America

Salvatore Albani

Affiliation Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, California, United States of America

Linda Sorkin

Affiliation Department of Anesthesiology, University of California San Diego School of Medicine, La Jolla, California, United States of America

Gary S Firestein

To whom correspondence should be addressed. E-mail: gfirestein@ucsd.edu

Affiliation Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DLB, SA, LS, and GSF designed the study. DLB, TLJ, LS, and GSF analyzed the data. DLB, CIS, LS, and GSF contributed to writing the paper. DH performed some of the Western blotting experiments discussed in the paper, and SR performed some of the in vivo studies.