About the Authors
- Smadar Eventov-Friedman
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Contributed equally to this work with: Smadar Eventov-Friedman, Dalit Tchorsh
Affiliation Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
- Dalit Tchorsh
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Contributed equally to this work with: Smadar Eventov-Friedman, Dalit Tchorsh
Affiliation Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
- Helena Katchman
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Affiliation Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
- Elias Shezen
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Affiliation Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
- Anna Aronovich
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Affiliation Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
- Gil Hecht
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Affiliation Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
- Benjamin Dekel
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Affiliation Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
- Gideon Rechavi
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Affiliation Pediatric Hemato-Oncology and Functional Genomics Unit, Sheba Medical Center, Tel Hashomer, Israel
- Bruce R Blazar
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Affiliation University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis, Minnesota, United States of America
- Ilan Feine
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Affiliation Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
- Orna Tal
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Affiliation Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
- Enrique Freud
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Affiliation Department of Pediatric Surgery, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel
- Yair Reisner
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*To whom correspondence should be addressed. E-mail: yair.reisner@weizmann.ac.il
Affiliation Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
Competing Interests
YR is a shareholder and Chair of the Scientific Advisory Board of Tissera, which supported this work. BD is a shareholder in Tissera.
Author Contributions
SEF, DT, HK, BRB, and YR designed the study. SEF, DT, HK, ES, AA, GH, GR, IF, OT, and EF collected data or did experiments for the study. DT was responsible mainly for the immunosuppressive part of the article, planning and analyzing results associated with reduced immunogenicity of the pig embryonic tissue and the immunocompetent mice. DT took part in many stages of most of the experiments described in the paper. ES was involved in performing the histological and immunohistological work. GH assisted in some of the transplantation experiments. IF assisted in antibody and drug administration to the mice. OT assisted with the transplantation procedures and with drug and antibody administration to the animals. EF was involved with the surgical procedures of pig pancreas implantation. SEF, DT, HK, GR, and YR analyzed the data. SEF, BD, BRB, and YR contributed to writing the paper.