About the Authors

Joanna L Jankowsky

To whom correspondence should be addressed. E-mail: jlj2@caltech.edu (JLJ); E-mail: borchelt@mbi.ufl.edu (DRB)

Affiliations Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Division of Biology, California Institute of Technology, Pasadena, California, United States of America

Hilda H Slunt

Address ¤ Current address: Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America

Affiliation Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Victoria Gonzales

Affiliation Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Alena V Savonenko

Affiliation Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Jason C Wen

Affiliation Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Nancy A Jenkins

Affiliation Mouse Cancer Genetics Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland, United States of America

Neal G Copeland

Affiliation Mouse Cancer Genetics Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, Maryland, United States of America

Linda H Younkin

Affiliation Mayo Clinic Jacksonville, Jacksonville, Florida, United States of America

Henry A Lester

Affiliation Division of Biology, California Institute of Technology, Pasadena, California, United States of America

Steven G Younkin

Affiliation Mayo Clinic Jacksonville, Jacksonville, Florida, United States of America

David R Borchelt

To whom correspondence should be addressed. E-mail: jlj2@caltech.edu (JLJ); E-mail: borchelt@mbi.ufl.edu (DRB)

Address ¤ Current address: Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America

Affiliations Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JLJ and DRB designed the study and wrote the manuscript, JLJ, HHS, VG, JCW, LHY, SGY and DRB performed experiments, NAJ and NGC generated transgenic founders, HAL assisted with data interpretation, and AVS performed statistical analyses.