About the Authors

Matthew L Batten

Affiliation Department of Ophthalmology, University of Washington, Seattle, Washington, United States of America

Yoshikazu Imanishi

Affiliations Department of Ophthalmology, University of Washington, Seattle, Washington, United States of America, Department of Pharmacology, Case School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

Daniel C Tu

Affiliation Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, United States of America

Thuy Doan

Affiliation Department of Physiology and Biophysics, University of Washington, Seattle, Washington, United States of America

Li Zhu

Affiliations Department of Ophthalmology, University of Washington, Seattle, Washington, United States of America, Department of Chemistry, University of Washington, Seattle, Washington, United States of America

Jijing Pang

Affiliation Department of Ophthalmology, and Powell Gene Therapy Center, University of Florida, Gainesville, Florida, United States of America

Lyudmila Glushakova

Affiliation Department of Ophthalmology, and Powell Gene Therapy Center, University of Florida, Gainesville, Florida, United States of America

Alexander R Moise

Affiliations Department of Ophthalmology, University of Washington, Seattle, Washington, United States of America, Department of Pharmacology, Case School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

Wolfgang Baehr

Affiliations Department of Ophthalmology, University of Utah, Salt Lake City, Utah, United States of America, Department of Biology, University of Utah, Salt Lake City, Utah, United States of America, Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah, United States of America

Russell N. Van Gelder

Affiliations Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Molecular Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Pharmacology, Washington University School of Medicine, St. Louis, Missouri, United States of America

William W Hauswirth

Affiliation Department of Ophthalmology, and Powell Gene Therapy Center, University of Florida, Gainesville, Florida, United States of America

Fred Rieke

Affiliation Department of Physiology and Biophysics, University of Washington, Seattle, Washington, United States of America

Krzysztof Palczewski

To whom correspondence should be addressed. E-mail: kxp65@case.edu

Affiliations Department of Ophthalmology, University of Washington, Seattle, Washington, United States of America, Department of Pharmacology, Case School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Department of Chemistry, University of Washington, Seattle, Washington, United States of America, Department of Pharmacology, University of Washington, Seattle, Washington, United States of America

Competing Interests

WWH and the University of Florida own equity in a company, Applied Genetic Technologies Corporation, that may commercialize some of the technology described in this work. KP owns shares of the company Retinagenix. The University of Washington and Retinagenix may commercialize some of the technology described in this work.

Author Contributions

MLB, YI, DCT, TD, LZ, JP, LG, ARM, WB, RNVG, WWH, FR, and KP contributed to conception and design, or acquisition of data, or analysis and interpretation of data. MLB, YI, DCT, TD, LZ, ARM, WB, RNVG, WWH, FR, and KP contributed to writing the paper.