About the Authors

Kitt F Petersen

Affiliation Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America

Sylvie Dufour

Affiliations Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America

Gerald I Shulman

Affiliations Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, United States of America, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America

Competing Interests

The authors have declared that no competing interests exist. GIS is a member of the editorial board of PLOS Medicine.

Author Contributions

KFP, SD, and GIS designed the study and analyzed the data. KFP enrolled patients. KFP, SD, and GIS contributed to writing the paper.