About the Authors

Shabir A Madhi

To whom correspondence should be addressed. E-mail: madhis@hivsa.com

Affiliations National Health Laboratory Service/University of the Witwatersrand/Medical Research Council Respiratory and Meningeal Pathogens Research Unit, University of the Witwatersrand, Johannesburg, South Africa, Paediatric Infectious Diseases Research Unit, Wits Health Consortium, University of the Witwatersrand, Johannesburg, South Africa

Jayvant R Heera

Affiliations National Health Laboratory Service/University of the Witwatersrand/Medical Research Council Respiratory and Meningeal Pathogens Research Unit, University of the Witwatersrand, Johannesburg, South Africa, Paediatric Infectious Diseases Research Unit, Wits Health Consortium, University of the Witwatersrand, Johannesburg, South Africa

Locadiah Kuwanda

Affiliation National Health Laboratory Service/University of the Witwatersrand/Medical Research Council Respiratory and Meningeal Pathogens Research Unit, University of the Witwatersrand, Johannesburg, South Africa

Keith P Klugman

Affiliations National Health Laboratory Service/University of the Witwatersrand/Medical Research Council Respiratory and Meningeal Pathogens Research Unit, University of the Witwatersrand, Johannesburg, South Africa, Department of International Health, Rollins School of Public Health, and Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, Georgia, United States of America

Competing Interests

The phase 3 study was supported by a grant from Wyeth-Lederle Vaccines and Pediatrics. SAM has received previous research support and consultancy fees from Wyeth Vaccines and Pediatrics. KPK has received previous research support and consultancy fees from Aventis, Bayer, GlaxoSmithKline, ID Biomedical, Oscient, Roche, and Wyeth-Ayerst.

Author Contributions

SAM, JRH, and KPK designed the study. SAM, JRH, LK, and KPK analyzed the data and contributed to writing the paper.