About the Authors

Michael Lehrke

Contributed equally to this work with: Michael Lehrke, Muredach P Reilly

Affiliation Divisions of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Muredach P Reilly

Contributed equally to this work with: Michael Lehrke, Muredach P Reilly

Affiliations Cardiology Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Experimental Therapeutics and Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Segan C Millington

Affiliation Divisions of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Nayyar Iqbal

Affiliation Divisions of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Daniel J Rader

Affiliations Cardiology Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Experimental Therapeutics and Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Mitchell A Lazar

Affiliation Divisions of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Competing Interests

MPR has received research funding or honoraria from GlaxoSmithKline, Merck, Ely Lilly, and KOS Pharmaceuticals. MAL has received a research grant from GlaxoSmithKline and has a United States patent application pending for therapeutic antagonism of human resistin. MAL and the University of Pennsylvania have licensed to Linco the monoclonal antibodies used in the human resistin assay.

Author Contributions

ML, MPR, NI, DJR, and MAL designed the study. ML, MPR, and SCM performed experiments. ML, MPR, NI, and MAL analyzed the data. MPR and NI enrolled patients. ML, MPR, NI, DJR, and MAL contributed to writing the paper. MAL obtained funding for the study and provided the research environment where the studies were conducted.