About the Authors

Søren D. Østergaard

Affiliations Research Department P, Aarhus University Hospital, Risskov, Denmark, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

Shubhabrata Mukherjee

Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

Stephen J. Sharp

Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

Petroula Proitsi

Affiliation Department of Basic and Clinical Neuroscience, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom

Luca A. Lotta

Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

Felix Day

Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

John R. B. Perry

Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

Kevin L. Boehme

Affiliation Department of Biology, Brigham Young University, Provo, Utah, United States of America

Stefan Walter

Affiliation Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, California, United States of America

John S. Kauwe

Affiliation Department of Biology, Brigham Young University, Provo, Utah, United States of America

Laura E. Gibbons

Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

Alzheimer’s Disease Genetics Consortium

Membership of the Alzheimer’s Disease Genetics Consortium, the Genetic and Environmental Risk in AD (GERAD1) Consortium, and the EPIC-InterAct Consortium is provided in S1 Text. Data used in the preparation of this article were obtained from GERAD1. As such, the investigators within GERAD1 contributed to the design and implementation of GERAD1 and/or provided data but did not participate in the analysis or writing of this report.

The GERAD1 Consortium

Membership of the Alzheimer’s Disease Genetics Consortium, the Genetic and Environmental Risk in AD (GERAD1) Consortium, and the EPIC-InterAct Consortium is provided in S1 Text. Data used in the preparation of this article were obtained from GERAD1. As such, the investigators within GERAD1 contributed to the design and implementation of GERAD1 and/or provided data but did not participate in the analysis or writing of this report.

EPIC-InterAct Consortium

Membership of the Alzheimer’s Disease Genetics Consortium, the Genetic and Environmental Risk in AD (GERAD1) Consortium, and the EPIC-InterAct Consortium is provided in S1 Text. Data used in the preparation of this article were obtained from GERAD1. As such, the investigators within GERAD1 contributed to the design and implementation of GERAD1 and/or provided data but did not participate in the analysis or writing of this report.

Eric B. Larson

Affiliations Department of Medicine, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Seattle, Washington, United States of America

John F. Powell

Affiliation Department of Basic and Clinical Neuroscience, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom

Claudia Langenberg

Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

Paul K. Crane

Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

Nicholas J. Wareham

Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

Robert A. Scott

Robert.Scott@mrc-epid.cam.ac.uk

Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

Competing Interests

SDØ has received speaking fees, consultant honoraria and travel support from Janssen-Cilag until April 2011. Furthermore, he has received travel support at one occasion in 2010 from Bristol-Myers Squibb. EBL reports grants from National Institute on Aging during the conduct of the study, and personal fees from UpToDate outside the submitted work. All other authors have nothing to disclose.

Author Contributions

Conceived and designed the experiments: SDØ SM SJS PP LAL JFP PKC NJW RAS. Analyzed the data: SDØ SM SJS PP LAL FD JRBP JP RAS. Wrote the first draft of the manuscript: SDØ SM PKC NJW RAS. Contributed to the writing of the manuscript: SDØ SM SJS PP LAL FD JRBP KLB SW JSK LEG EBL JFP CL PKC NJW RAS. Agree with manuscript results and conclusions: SDØ SM SJS PP LAL FD JRBP KLB SW JSK LEG EBL JFP CL PKC NJW RAS. All authors have read, and confirm that they meet, ICMJE criteria for authorship.