About the Authors
- Caryn S. Ross-Innes
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Affiliation MRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom
- Irene Debiram-Beecham
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Affiliation MRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom
- Maria O'Donovan
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Affiliation Department of Histopathology, Addenbrooke's Hospital, Cambridge, United Kingdom
- Elaine Walker
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Affiliation MRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom
- Sibu Varghese
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Affiliation MRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom
- Pierre Lao-Sirieix
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Affiliation MRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom
- Laurence Lovat
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Affiliation University College London Hospital, London, United Kingdom
- Michael Griffin
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Affiliation Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
- Krish Ragunath
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Affiliation Nottingham Queen's Medical Centre, Nottingham, United Kingdom
- Rehan Haidry
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Affiliation University College London Hospital, London, United Kingdom
- Sarmed S. Sami
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Affiliation Nottingham Queen's Medical Centre, Nottingham, United Kingdom
- Philip Kaye
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Affiliation Nottingham Queen's Medical Centre, Nottingham, United Kingdom
- Marco Novelli
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Affiliation University College London Hospital, London, United Kingdom
- Babett Disep
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Affiliation Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
- Richard Ostler
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Affiliation Cancer Prevention Trials Unit, London, United Kingdom
- Benoit Aigret
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Affiliation Cancer Prevention Trials Unit, London, United Kingdom
- Bernard V. North
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Affiliation Cancer Prevention Trials Unit, London, United Kingdom
- Pradeep Bhandari
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Affiliation Queen Alexandra Hospital, Portsmouth, United Kingdom
- Adam Haycock
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Affiliation St Mark's Hospital, London, United Kingdom
- Danielle Morris
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Affiliation East and North Hertfordshire NHS Trust–QEII and Lister Hospitals, Welwyn Garden City and Stevenage, United Kingdom
- Stephen Attwood
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Affiliations Northern Region Endoscopy Group, United Kingdom, North Tyneside General Hospital, North Shields, United Kingdom
- Anjan Dhar
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Affiliations Northern Region Endoscopy Group, United Kingdom, County Durham and Darlington NHS Foundation Trust, Durham, United Kingdom
- Colin Rees
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Affiliations Northern Region Endoscopy Group, United Kingdom, South Tyneside NHS Foundation Trust, South Shields, United Kingdom
- Matthew D. D. Rutter
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Affiliations Northern Region Endoscopy Group, United Kingdom, North Tees and Hartlepool NHS Foundation Trust, Stockton-on-Tees, United Kingdom
- Peter D. Sasieni
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Affiliation Cancer Prevention Trials Unit, London, United Kingdom
- Rebecca C. Fitzgerald
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* E-mail: rcf29@MRC-CU.cam.ac.uk
Affiliation MRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom
- on behalf of the BEST2 Study Group
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¶Membership of the BEST2 Study Group is provided in the Acknowledgments.
Competing Interests
The Addenbrooke's Hospital Human Research Tissue Bank, supported by the NIHR Cambridge Biomedical Research Centre, supported this study. This study was funded by a project grant from Cancer Research UK. The device was designed by RCF and her research team in between 2009 and 2010. Patents and a trademark were filed in 2010 by the Medical Research Council (MRC). The BEST2 study was designed in 2010 and the device was manufactured for the specific purpose of this study following a letter of no objection from the Medical Health Regulatory Agency. In 2013 the MRC licensed the technology to Covidien GI Solutions. They have had no influence in any way on the design, conduct or analysis of this trial and the manuscript was not disclosed to them until after acceptance for publication. RCF, MOD and PLS are named inventors on patents pertaining to the Cytosponge and related assays. They have not received any financial benefits to date. Since December 2013, after completion of this study, PLS is now employed partly by Covidien GI Solutions. All other authors have no conflicts of interest to declare. RCF has programmatic funding from the Medical Research Council and infrastructure support from the Biomedical Research Centre and the Experimental Medicine Centre. MDDR has received travel reimbursement for conferences (Abbvie 2014), honoraria (Dr Falk 2013), unrestricted grant research (Olympus 2014) and shares (AstraZeneca, held for >20 years).
Author Contributions
Conceived and designed the experiments: RCF PDS. Performed the experiments: CSRI EW MOD. Analyzed the data: CSRI RCF. Wrote the paper: RCF CSRI PLS. Constructed the figures: CSRI PLS. Co-ordinated the study: IDB. Involved in data collection: CSRI IDB MOD EW SV LL MG KR RH SSS PB AH DM SA AD CR MDDR. Involved with pathology review: MOD PK MN BD. Built the study database: RO. Clinical manager: BA. Did the statistical analysis: BVN PDS. Enrolled patients: IDB. Agree with manuscript results and conclusions: CSRI IDB MOD EW SV PLS LL MG KR RH SSS PK MN BD RO BA BVN PB AH DM SA AD CR MDDR PDS RCF. All authors have read, and confirm that they meet, ICMJE criteria for authorship.