About the Authors

Timothy A Chan

¤ Current address: Human Oncology and Pathogenesis Program and Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America

Affiliations Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America , Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America

Sabine Glockner

Affiliations Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America , Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland, United States of America

Joo Mi Yi

Affiliation Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America

Wei Chen

Affiliations Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America , Predoctoral Training Program in Human Genetics, The Johns Hopkins University, Baltimore, Maryland, United States of America

Leander Van Neste

Affiliation Department of Molecular Biotechnology, Ghent University, Ghent, Belgium

Leslie Cope

Affiliation Biometry and Clinical Trials Division, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America

James G Herman

Affiliation Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America

Victor Velculescu

Affiliations Ludwig Center for Cancer Genetics and Therapeutics, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America , Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America

Kornel E Schuebel

To whom correspondence should be addressed. E-mail: sbaylin@jhmi.edu (SBB); kornels@jhmi.edu (KES); nahuja@jhmi.ed (NA)

Affiliation Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America

Nita Ahuja

To whom correspondence should be addressed. E-mail: sbaylin@jhmi.edu (SBB); kornels@jhmi.edu (KES); nahuja@jhmi.ed (NA)

Affiliations Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America , Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland, United States of America

Stephen B Baylin

To whom correspondence should be addressed. E-mail: sbaylin@jhmi.edu (SBB); kornels@jhmi.edu (KES); nahuja@jhmi.ed (NA)

Affiliations Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America , Predoctoral Training Program in Human Genetics, The Johns Hopkins University, Baltimore, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

TAC and SBB designed the study. TAC and SG performed the experiments for the study. TAC, VV, KES, and SBB analyzed the data and interpreted the results. TAC, WC, LVN, LC, and JGH contributed bioinformatics and statistical analysis to the research effort. TAC and SBB wrote the manuscript. NA enrolled patients and helped analyze the clinical outcomes data. JMY performed a portion of the bisulfite sequencing analysis of the common target.