About the Authors

Michael J Sorich

Contributed equally to this work with: Michael J Sorich, Nicolas Pottier

Affiliations Hematological Malignancies Program and the Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America , Sansom Institute, University of South Australia, Adelaide, Australia

Nicolas Pottier

Contributed equally to this work with: Michael J Sorich, Nicolas Pottier

Affiliations Hematological Malignancies Program and the Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America , EA2679, Faculté de Médecine de Lille, Pole Recherche, Lille, France

Deqing Pei

Affiliation Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

Wenjian Yang

Affiliation Hematological Malignancies Program and the Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

Leo Kager

Affiliations Hematological Malignancies Program and the Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America , Department of Hematology-Oncology, St. Anna Children's Hospital, Vienna, Austria

Gabriele Stocco

Affiliations Hematological Malignancies Program and the Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America , Instituto di Ricovero e Cura a Carattere Scientifico, Burlo Garofolo and University of Trieste, Trieste, Italy

Cheng Cheng

Affiliation Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

John C Panetta

Affiliations Hematological Malignancies Program and the Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America , University of Tennessee, Memphis, Tennessee, United States of America

Ching-Hon Pui

Affiliations University of Tennessee, Memphis, Tennessee, United States of America , Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

Mary V Relling

Affiliations Hematological Malignancies Program and the Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America , University of Tennessee, Memphis, Tennessee, United States of America , Pharmacogenetics of Anticancer Agents Research Group, National Institutes of Health Pharmacogenetics Research Network, Memphis, Tennessee, United States of America, and Chicago, Illinois, United States of America

Meyling H Cheok

Affiliations Hematological Malignancies Program and the Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America , University of Tennessee, Memphis, Tennessee, United States of America

William E Evans

To whom correspondence should be addressed. E-mail: william.evans@stjude.org

Affiliations Hematological Malignancies Program and the Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America , University of Tennessee, Memphis, Tennessee, United States of America , Pharmacogenetics of Anticancer Agents Research Group, National Institutes of Health Pharmacogenetics Research Network, Memphis, Tennessee, United States of America, and Chicago, Illinois, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MJS, C-HP, MHC, and WEE designed the experiments and the study. MJS, DP, WY, GS, CC, JCP, MVR, WEE, and MHC analyzed the data. C-HP enrolled and treated patients. NP wrote the first draft of the paper. MJS, WY, LK, GS, CC, C-HP, MVR, MHC, and WEE contributed to writing the paper. MHC collected gene expression and patient data for this study.