Factors Associated with Findings of Published Trials of Drug–Drug Comparisons: Why Some Statins Appear More Efficacious than Others

Lisa Bero; Fieke Oostvogel; Peter Bacchetti; Kirby Lee

doi:10.1371/journal.pmed.0040184

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Open Access

Peer-reviewed

Research Article

Factors Associated with Findings of Published Trials of Drug–Drug Comparisons: Why Some Statins Appear More Efficacious than Others

Lisa Bero ,

*To whom correspondence should be addressed. E-mail: berol@pharmacy.ucsf.edu

Affiliation Clinical Pharmacy and Health Policy, University of California, San Francisco, California, United States of America
⨯
Fieke Oostvogel,

Affiliation Department of Mathematics, University of Leiden, The Netherlands
⨯
Peter Bacchetti,

Affiliation Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America
⨯
Kirby Lee

Affiliation Department of Clinical Pharmacy, University of California, San Francisco, California, United States of America
⨯

Factors Associated with Findings of Published Trials of Drug–Drug Comparisons: Why Some Statins Appear More Efficacious than Others

Lisa Bero,
Fieke Oostvogel,
Peter Bacchetti,
Kirby Lee

Published: June 5, 2007
https://doi.org/10.1371/journal.pmed.0040184

About the Authors

Lisa Bero

*To whom correspondence should be addressed. E-mail: berol@pharmacy.ucsf.edu

Affiliation Clinical Pharmacy and Health Policy, University of California, San Francisco, California, United States of America

Fieke Oostvogel

Affiliation Department of Mathematics, University of Leiden, The Netherlands

Peter Bacchetti

Affiliation Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America

Kirby Lee

Affiliation Department of Clinical Pharmacy, University of California, San Francisco, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

LB designed the study, analyzed data, and drafted the manuscript. FO collected data. KL advised on study design. LB, FO, and KL coded data. FO, PB, and KL advised on analysis. PB conducted analysis. FO, PB, and KL revised the paper.

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Statins
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Randomized controlled trials
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Drug discovery
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Drug research and development
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Finance
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Comparators
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