About the Authors

Kazuya Takahashi

Affiliations Neural Regeneration Unit, Institute of Reconstructive Neurobiology, University of Bonn Life & Brain Center and Hertie-Foundation, Bonn, Germany , Neuroimmunology Unit, European Neuroscience Institute Göttingen, Göttingen, Germany

Marco Prinz

Affiliation Department of Neuropathology, University Hospital Göttingen, Göttingen, Germany

Massimiliano Stagi

Affiliations Neural Regeneration Unit, Institute of Reconstructive Neurobiology, University of Bonn Life & Brain Center and Hertie-Foundation, Bonn, Germany , Neuroimmunology Unit, European Neuroscience Institute Göttingen, Göttingen, Germany , Institute of Multiple Sclerosis Research, University of Göttingen and Hertie-Foundation, Germany

Olga Chechneva

Affiliation Neural Regeneration Unit, Institute of Reconstructive Neurobiology, University of Bonn Life & Brain Center and Hertie-Foundation, Bonn, Germany

Harald Neumann

To whom correspondence should be addressed. E-mail: hneuman1@uni-bonn.de

Affiliations Neural Regeneration Unit, Institute of Reconstructive Neurobiology, University of Bonn Life & Brain Center and Hertie-Foundation, Bonn, Germany , Neuroimmunology Unit, European Neuroscience Institute Göttingen, Göttingen, Germany , Institute of Multiple Sclerosis Research, University of Göttingen and Hertie-Foundation, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KT and HN designed the study. KT, MP, OC, and HN analyzed the data. KT, MP, and HN contributed to writing the paper. MP collected data or did experiments for the study. KT did most of the experiments and collecting of data for this paper except for the confocal works, histological works, and TREM2-expression study shown in Figure 1. MS performed fluorescence imaging. OC contributed the data presented in Figure 1.