About the Authors

Caroline L Smith

To whom correspondence should be addressed. E-mail: c.l.smith@ucl.ac.uk

Affiliation Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, University College London, London, United Kingdom

Shelagh Anthony

Affiliation Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, University College London, London, United Kingdom

Mike Hubank

Affiliation Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, University College London, London, United Kingdom

James M Leiper

Affiliation Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, University College London, London, United Kingdom

Patrick Vallance

Affiliation Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, University College London, London, United Kingdom

Competing Interests

University College London holds patents on DDAH as a drug target (not relevant to the present study).

Author Contributions

CLS, JML, and PV designed the study. CLS, SA, MH, JML, and PV analyzed the data. CLS, MH, JML, and PV contributed to writing the paper.