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Oas2 activation results in lactation failure.

Artist impression of localised lactation failure restricted to a mammary ductal branch while the remaining breast continues to lactate. Here, Oakes et al. show that mutation of Oas2 activated viral sensing within murine mammary glands and resulted in decreased milk protein synthesis, loss of proliferation, increased apoptosis and a robust interferon response. Activation of the Oas2 pathway could provide an evolutionary conserved mechanism to prevent viral transmission via milk. See Oakes et al.

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Image Credit: Dr. Samantha R. Oakes. Pencil on paper.