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Challenging the Wnt signaling dogma.

Armadillo and Pangolin interaction represents the hallmark of the Wnt/Wingless (Wg) signaling response. Whether other interacting partners and alternative transcriptional complexes interfere with the canonical Wnt/Wg signaling pathway has long remained elusive. By applying large-scale quantitative genetic approaches, Franz et al. show that in Drosophila cells all Wnt/Wg signals proceed through Armadillo and Pangolin, and Wnt/Wg-responsive enhancers fully depend on the presence of Pangolin. The image shows the animals Armadillo and Pangolin on top of nucleotide sequences, illustrating their control over Wingless-responsive genes and enhancers. See Franz et al.

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Image Credit: Alexandra Franz