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Nucleocytoplasmic transport and nuclear membrane expansion are critical for nuclear size control.
How membrane-bound organelles are maintained at an appropriate size during cell growth and division is poorly understood. The simply shaped S. pombe nucleus undergoes a closed mitosis in a single copy within a cell, making it a useful system for studying organelle size homeostasis. Kume et al. carried out a near genome-wide screen for fission yeast mutants with altered nuclear size and show that nucleocytoplasmic transport and appropriately regulated nuclear membrane expansion are central to nuclear size control. Shown here are the nuclear envelopes of wild-type (cyan) and nuclear size mutant (green) fission yeast cells. See Kume et al.
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Image Credit: Kazunori Kume, Hiroshima University