In order to consolidate and evaluate the current literature regarding the major histocompatibility complex in six genetically complex disease traits, the authors performed a review and pooled analysis of the past 30 years of research.
Using a genome-wide association approach, the authors show that common genetic variation influences levels of clinically relevant proteins in human serum and plasma.
These analyses revealed eight new L-type calcium channel residues that are important for DHP-sensitivity and highlight the utility of using a simple animal model system for understanding how drugs interact with their targets.
The authors conclude that along with mutation, selection and drift, biased gene conversion is one of the major factors driving genome evolution.
PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS Pathogens; PLoS ONE; PLoS Neglected Tropical Diseases
PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS Neglected Tropical Diseases
PLoS Genetics is a peer-reviewed, open-access journal that reflects the full breadth and interdisciplinary nature of genetics and genomics research by publishing outstanding original contributions in all areas of biology. View a list of Google Scholar citations and read about our first ISI impact factor of 7.67.
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