Armadillo and Pangolin interaction represents the hallmark of the Wnt/Wingless (Wg) signaling response. Whether other interacting partners and alternative transcriptional complexes interfere with the canonical Wnt/Wg signaling pathway has long remained elusive. By applying large-scale quantitative genetic approaches, Franz et al. show that in Drosophila cells all Wnt/Wg signals proceed through Armadillo and Pangolin, and Wnt/Wg-responsive enhancers fully depend on the presence of Pangolin. The image shows the animals Armadillo and Pangolin on top of nucleotide sequences, illustrating their control over Wingless-responsive genes and enhancers. See Franz et al.
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Image Credit: Alexandra Franz
Review
What is adaptation by natural selection? Perspectives of an experimental microbiologist
PLOS Genetics: published April 20, 2017 | https://doi.org/10.1371/journal.pgen.1006668
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PLOS Genetics: published April 27, 2017 | https://doi.org/10.1371/journal.pgen.1006748
Natural variation of piRNA expression affects immunity to transposable elements
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Evolutionary history of Tibetans inferred from whole-genome sequencing
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Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions
PLOS Genetics: published April 18, 2017 | https://doi.org/10.1371/journal.pgen.1006714
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PLOS Genetics: published April 17, 2017 | https://doi.org/10.1371/journal.pgen.1006743
Neuronal cell fate specification by the molecular convergence of different spatio-temporal cues on a common initiator terminal selector gene
PLOS Genetics: published April 17, 2017 | https://doi.org/10.1371/journal.pgen.1006729
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Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experiments
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Retraction
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