January 2015

Plants include both the green algae and land plants. Multiple times, root, stem and leaf-like structures arose independently in plant lineages. In some instances, such as the siphonous algae, these structures arose in the absence of multicellularity. The partitioning of gene transcripts within what is debatably the largest single-celled organism in the world, the siphonous alga Caulerpa taxifolia, is explored. The recurrent recruitment of transcripts to organs—in both a green alga and land plant—suggests land plant morphology is not as influenced by emergent cellular properties as organismal-level processes. Shown is the frond apex of C. taxifolia, producing young pinnule primordia. See Ranjan et al.

Image Credit: Daniel H. Chitwood, Donald Danforth Plant Science Center, St. Louis, Missouri, United States of America

Perspectives

Ataxin-3, DNA Damage Repair, and SCA3 Cerebellar Degeneration: On the Path to Parsimony?

Jacqueline M. Ward, Albert R. La Spada

PLOS Genetics: published January 29, 2015 | https://doi.org/10.1371/journal.pgen.1004937

A Polyubiquitin Chain Reaction: Parkin Recruitment to Damaged Mitochondria

Brigit E. Riley, James A. Olzmann

PLOS Genetics: published January 22, 2015 | https://doi.org/10.1371/journal.pgen.1004952

α-Actinin-3: Why Gene Loss Is an Evolutionary Gain

Niklas Ivarsson, Håkan Westerblad

PLOS Genetics: published January 15, 2015 | https://doi.org/10.1371/journal.pgen.1004908

The Combination of Random Mutagenesis and Sequencing Highlight the Role of Unexpected Genes in an Intractable Organism

Damien Faivre, Jens Baumgartner

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004895

Regulating Maf1 Expression and Its Expanding Biological Functions

Robyn D. Moir, Ian M. Willis

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004896

Reviews

The Genetic and Mechanistic Basis for Variation in Gene Regulation

Athma A. Pai, Jonathan K. Pritchard, Yoav Gilad

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004857

End of the Beginning: Elongation and Termination Features of Alternative Modes of Chromosomal Replication Initiation in Bacteria

Jayaraman Gowrishankar

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004909

Research Articles

ALIX and ESCRT-III Coordinately Control Cytokinetic Abscission during Germline Stem Cell Division In Vivo

Åsmund H. Eikenes, Lene Malerød, Anette Lie Christensen, Chloé B. Steen, Juliette Mathieu, Ioannis P. Nezis, Knut Liestøl, Jean-René Huynh, Harald Stenmark, Kaisa Haglund

PLOS Genetics: published January 30, 2015 | https://doi.org/10.1371/journal.pgen.1004904

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

Arpita Chatterjee, Saikat Saha, Anirban Chakraborty, Anabela Silva-Fernandes, Santi M. Mandal, Andreia Neves-Carvalho, Yongping Liu, Raj K. Pandita, Muralidhar L. Hegde, Pavana M. Hegde, Istvan Boldogh, Tetsuo Ashizawa, Arnulf H. Koeppen, Tej K. Pandita, Patricia Maciel, Partha S. Sarkar, Tapas K. Hazra

PLOS Genetics: published January 29, 2015 | https://doi.org/10.1371/journal.pgen.1004749

A dPIP5K Dependent Pool of Phosphatidylinositol 4,5 Bisphosphate (PIP₂) Is Required for G-Protein Coupled Signal Transduction in Drosophila Photoreceptors

Purbani Chakrabarti, Sourav Kolay, Shweta Yadav, Kamalesh Kumari, Amit Nair, Deepti Trivedi, Padinjat Raghu

PLOS Genetics: published January 29, 2015 | https://doi.org/10.1371/journal.pgen.1004948

Polycomb Protein SCML2 Associates with USP7 and Counteracts Histone H2A Ubiquitination in the XY Chromatin during Male Meiosis

Mengcheng Luo, Jian Zhou, N. Adrian Leu, Carla M. Abreu, Jianle Wang, Montserrat C. Anguera, Dirk G. de Rooij, Maria Jasin, P. Jeremy Wang

PLOS Genetics: published January 29, 2015 | https://doi.org/10.1371/journal.pgen.1004954

Tissue-Specific Effects of Genetic and Epigenetic Variation on Gene Regulation and Splicing

Maria Gutierrez-Arcelus, Halit Ongen, Tuuli Lappalainen, Stephen B. Montgomery, Alfonso Buil, Alisa Yurovsky, Julien Bryois, Ismael Padioleau, Luciana Romano, Alexandra Planchon, Emilie Falconnet, Deborah Bielser, Maryline Gagnebin, Thomas Giger, Christelle Borel, Audrey Letourneau, Periklis Makrythanasis, Michel Guipponi, Corinne Gehrig, Stylianos E. Antonarakis, Emmanouil T. Dermitzakis

PLOS Genetics: published January 29, 2015 | https://doi.org/10.1371/journal.pgen.1004958

MiR-24 Is Required for Hematopoietic Differentiation of Mouse Embryonic Stem Cells

Lynn Roy, Emmanuel Bikorimana, Danica Lapid, Hyewon Choi, Tan Nguyen, Richard Dahl

PLOS Genetics: published January 29, 2015 | https://doi.org/10.1371/journal.pgen.1004959

Antagonistic Cross-Regulation between Sox9 and Sox10 Controls an Anti-tumorigenic Program in Melanoma

Olga Shakhova, Phil Cheng, Pravin J. Mishra, Daniel Zingg, Simon M. Schaefer, Julien Debbache, Jessica Häusel, Claudia Matter, Theresa Guo, Sean Davis, Paul Meltzer, Daniela Mihic-Probst, Holger Moch, Michael Wegner, Glenn Merlino, Mitchell P. Levesque, Reinhard Dummer, Raffaella Santoro, Paolo Cinelli, Lukas Sommer

PLOS Genetics: published January 28, 2015 | https://doi.org/10.1371/journal.pgen.1004877

Imputation of the Rare HOXB13 G84E Mutation and Cancer Risk in a Large Population-Based Cohort

Thomas J. Hoffmann, Lori C. Sakoda, Ling Shen, Eric Jorgenson, Laurel A. Habel, Jinghua Liu, Mark N. Kvale, Maryam M. Asgari, Yambazi Banda, Douglas Corley, Lawrence H. Kushi, Charles P. Quesenberry Jr., Catherine Schaefer, Stephen K. Van Den Eeden, Neil Risch, John S. Witte

PLOS Genetics: published January 28, 2015 | https://doi.org/10.1371/journal.pgen.1004930

DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining

Sean M. Howard, Diana A. Yanez, Jeremy M. Stark

PLOS Genetics: published January 28, 2015 | https://doi.org/10.1371/journal.pgen.1004943

Proteasomes, Sir2, and Hxk2 Form an Interconnected Aging Network That Impinges on the AMPK/Snf1-Regulated Transcriptional Repressor Mig1

Yanhua Yao, Scott Tsuchiyama, Ciyu Yang, Anne Laure Bulteau, Chong He, Brett Robison, Mitsuhiro Tsuchiya, Delana Miller, Valeria Briones, Krisztina Tar, Anahi Potrero, Bertrand Friguet, Brian K. Kennedy, Marion Schmidt

PLOS Genetics: published January 28, 2015 | https://doi.org/10.1371/journal.pgen.1004968

Genetic Variants Modulating CRIPTO Serum Levels Identified by Genome-Wide Association Study in Cilento Isolates

Daniela Ruggiero, Stefania Nappo, Teresa Nutile, Rossella Sorice, Francesco Talotta, Emilia Giorgio, Celine Bellenguez, Anne-Louise Leutenegger, Giovanna L. Liguori, Marina Ciullo

PLOS Genetics: published January 28, 2015 | https://doi.org/10.1371/journal.pgen.1004976

Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus

Anubha Mahajan, Xueling Sim, Hui Jin Ng, Alisa Manning, Manuel A. Rivas, Heather M. Highland, Adam E. Locke, Niels Grarup, Hae Kyung Im, Pablo Cingolani, Jason Flannick, Pierre Fontanillas, Christian Fuchsberger, Kyle J. Gaulton, Tanya M. Teslovich, N. William Rayner, Neil R. Robertson, Nicola L. Beer, Jana K. Rundle, Jette Bork-Jensen, Claes Ladenvall, Christine Blancher, David Buck, Gemma Buck, Noël P. Burtt, Stacey Gabriel, Anette P. Gjesing, Christopher J. Groves, Mette Hollensted, Jeroen R. Huyghe, Anne U. Jackson, Goo Jun, Johanne Marie Justesen, Massimo Mangino, Jacquelyn Murphy, Matt Neville, Robert Onofrio, Kerrin S. Small, Heather M. Stringham, Ann-Christine Syvänen, Joseph Trakalo, Goncalo Abecasis, Graeme I. Bell, John Blangero, Nancy J. Cox, Ravindranath Duggirala, Craig L. Hanis, Mark Seielstad, James G. Wilson, Cramer Christensen, Ivan Brandslund, Rainer Rauramaa, Gabriela L. Surdulescu, Alex S. F. Doney, Lars Lannfelt, Allan Linneberg, Bo Isomaa, Tiinamaija Tuomi, Marit E. Jørgensen, Torben Jørgensen, Johanna Kuusisto, Matti Uusitupa, Veikko Salomaa, Timothy D. Spector, Andrew D. Morris, Colin N. A. Palmer, Francis S. Collins, Karen L. Mohlke, Richard N. Bergman, Erik Ingelsson, Lars Lind, Jaakko Tuomilehto, Torben Hansen, Richard M. Watanabe, Inga Prokopenko, Josee Dupuis, Fredrik Karpe, Leif Groop, Markku Laakso, Oluf Pedersen, Jose C. Florez, Andrew P. Morris, David Altshuler, James B. Meigs, Michael Boehnke, Mark I. McCarthy, Cecilia M. Lindgren, Anna L. Gloyn, On Behalf of the T2D-GENES consortium and GoT2D consortium

PLOS Genetics: published January 27, 2015 | https://doi.org/10.1371/journal.pgen.1004876

No Evidence for Association of Autism with Rare Heterozygous Point Mutations in Contactin-Associated Protein-Like 2 (CNTNAP2), or in Other Contactin-Associated Proteins or Contactins

John D. Murdoch, Abha R. Gupta, Stephan J. Sanders, Michael F. Walker, John Keaney, Thomas V. Fernandez, Michael T. Murtha, Samuel Anyanwu, Gordon T. Ober, Melanie J. Raubeson, Nicholas M. DiLullo, Natalie Villa, Zainabdul Waqar, Catherine Sullivan, Luis Gonzalez, A. Jeremy Willsey, So-Yeon Choe, Benjamin M. Neale, Mark J. Daly, Matthew W. State

PLOS Genetics: published January 26, 2015 | https://doi.org/10.1371/journal.pgen.1004852

Naturally Occurring Differences in CENH3 Affect Chromosome Segregation in Zygotic Mitosis of Hybrids

Shamoni Maheshwari, Ek Han Tan, Allan West, F. Chris H. Franklin, Luca Comai, Simon W. L. Chan

PLOS Genetics: published January 26, 2015 | https://doi.org/10.1371/journal.pgen.1004970

Deciphering the Genetic Programme Triggering Timely and Spatially-Regulated Chitin Deposition

Bernard Moussian, Annalisa Letizia, Guillermo Martínez-Corrales, Bárbara Rotstein, Andreu Casali, Marta Llimargas

PLOS Genetics: published January 24, 2015 | https://doi.org/10.1371/journal.pgen.1004939

Aberrant Gene Expression in Humans

Yong Zeng, Gang Wang, Ence Yang, Guoli Ji, Candice L. Brinkmeyer-Langford, James J. Cai

PLOS Genetics: published January 24, 2015 | https://doi.org/10.1371/journal.pgen.1004942

A Truncated NLR Protein, TIR-NBS2, Is Required for Activated Defense Responses in the exo70B1 Mutant

Ting Zhao, Lu Rui, Juan Li, Marc T. Nishimura, John P. Vogel, Na Liu, Simu Liu, Yaofei Zhao, Jeffery L. Dangl, Dingzhong Tang

PLOS Genetics: published January 24, 2015 | https://doi.org/10.1371/journal.pgen.1004945

The Intersection of the Extrinsic Hedgehog and WNT/Wingless Signals with the Intrinsic Hox Code Underpins Branching Pattern and Tube Shape Diversity in the Drosophila Airways

Ryo Matsuda, Chie Hosono, Kaoru Saigo, Christos Samakovlis

PLOS Genetics: published January 23, 2015 | https://doi.org/10.1371/journal.pgen.1004929

The Arabidopsis SWI2/SNF2 Chromatin Remodeler BRAHMA Regulates Polycomb Function during Vegetative Development and Directly Activates the Flowering Repressor Gene SVP

Chenlong Li, Chen Chen, Lei Gao, Songguang Yang, Vi Nguyen, Xuejiang Shi, Katherine Siminovitch, Susanne E. Kohalmi, Shangzhi Huang, Keqiang Wu, Xuemei Chen, Yuhai Cui

PLOS Genetics: published January 23, 2015 | https://doi.org/10.1371/journal.pgen.1004944

Estrogenic Exposure Alters the Spermatogonial Stem Cells in the Developing Testis, Permanently Reducing Crossover Levels in the Adult

Lisa A. Vrooman, Jon M. Oatley, Jodi E. Griswold, Terry J. Hassold, Patricia A. Hunt

PLOS Genetics: published January 23, 2015 | https://doi.org/10.1371/journal.pgen.1004949

Evolutionary Constraint and Disease Associations of Post-Translational Modification Sites in Human Genomes

Jüri Reimand, Omar Wagih, Gary D. Bader

PLOS Genetics: published January 22, 2015 | https://doi.org/10.1371/journal.pgen.1004919

hnRNP K Coordinates Transcriptional Silencing by SETDB1 in Embryonic Stem Cells

Peter J. Thompson, Vered Dulberg, Kyung-Mee Moon, Leonard J. Foster, Carol Chen, Mohammad M. Karimi, Matthew C. Lorincz

PLOS Genetics: published January 22, 2015 | https://doi.org/10.1371/journal.pgen.1004933

Fascin1-Dependent Filopodia are Required for Directional Migration of a Subset of Neural Crest Cells

Elena F. Boer, Elizabeth D. Howell, Thomas F. Schilling, Cicely A. Jette, Rodney A. Stewart

PLOS Genetics: published January 21, 2015 | https://doi.org/10.1371/journal.pgen.1004946

Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

Rui Gao, Yongping Liu, Anabela Silva-Fernandes, Xiang Fang, Adriana Paulucci-Holthauzen, Arpita Chatterjee, Hang L. Zhang, Tohru Matsuura, Sanjeev Choudhary, Tetsuo Ashizawa, Arnulf H. Koeppen, Patricia Maciel, Tapas K. Hazra, Partha S. Sarkar

PLOS Genetics: published January 15, 2015 | https://doi.org/10.1371/journal.pgen.1004834

Altered Ca²⁺ Kinetics Associated with α-Actinin-3 Deficiency May Explain Positive Selection for ACTN3 Null Allele in Human Evolution

Stewart I. Head, Stephen Chan, Peter J. Houweling, Kate G. R. Quinlan, Robyn Murphy, Sören Wagner, Oliver Friedrich, Kathryn N. North

PLOS Genetics: published January 15, 2015 | https://doi.org/10.1371/journal.pgen.1004862

Genetic Variation in the Nuclear and Organellar Genomes Modulates Stochastic Variation in the Metabolome, Growth, and Defense

Bindu Joseph, Jason A. Corwin, Daniel J. Kliebenstein

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004779

A Genetic Strategy for Probing the Functional Diversity of Magnetosome Formation

Lilah Rahn-Lee, Meghan E. Byrne, Manjing Zhang, David Le Sage, David R. Glenn, Timothy Milbourne, Ronald L. Walsworth, Hojatollah Vali, Arash Komeili

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004811

Heterologous Aggregates Promote De Novo Prion Appearance via More than One Mechanism

Fatih Arslan, Joo Y. Hong, Vydehi Kanneganti, Sei-Kyoung Park, Susan W. Liebman

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004814

The Global Regulatory Architecture of Transcription during the Caulobacter Cell Cycle

Bo Zhou, Jared M. Schrader, Virginia S. Kalogeraki, Eduardo Abeliuk, Cong B. Dinh, James Q. Pham, Zhongying Z. Cui, David L. Dill, Harley H. McAdams, Lucy Shapiro

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004831

Insight in Genome-Wide Association of Metabolite Quantitative Traits by Exome Sequence Analyses

Ayşe Demirkan, Peter Henneman, Aswin Verhoeven, Harish Dharuri, Najaf Amin, Jan Bert van Klinken, Lennart C. Karssen, Boukje de Vries, Axel Meissner, Sibel Göraler, Arn M. J. M. van den Maagdenberg, André M. Deelder, Peter A. C ’t Hoen, Cornelia M. van Duijn, Ko Willems van Dijk

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004835

Developmental Regulation of the Tetrahymena thermophila Origin Recognition Complex

Po-Hsuen Lee, Xiangzhou Meng, Geoffrey M. Kapler

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004875

Interactions of Chromatin Context, Binding Site Sequence Content, and Sequence Evolution in Stress-Induced p53 Occupancy and Transactivation

Dan Su, Xuting Wang, Michelle R. Campbell, Lingyun Song, Alexias Safi, Gregory E. Crawford, Douglas A. Bell

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004885

Transcriptional Control of an Essential Ribozyme in Drosophila Reveals an Ancient Evolutionary Divide in Animals

Sathiya N. Manivannan, Lien B. Lai, Venkat Gopalan, Amanda Simcox

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004893

A Discrete Transition Zone Organizes the Topological and Regulatory Autonomy of the Adjacent Tfap2c and Bmp7 Genes

Taro Tsujimura, Felix A. Klein, Katja Langenfeld, Juliane Glaser, Wolfgang Huber, François Spitz

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004897

Integrative Analysis of DNA Methylation and Gene Expression Data Identifies EPAS1 as a Key Regulator of COPD

Seungyeul Yoo, Sachiko Takikawa, Patrick Geraghty, Carmen Argmann, Joshua Campbell, Luan Lin, Tao Huang, Zhidong Tu, Robert Feronjy, Avrum Spira, Eric E. Schadt, Charles A. Powell, Jun Zhu

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004898

Sumoylation Influences DNA Break Repair Partly by Increasing the Solubility of a Conserved End Resection Protein

Prabha Sarangi, Roland Steinacher, Veronika Altmannova, Qiong Fu, Tanya T. Paull, Lumir Krejci, Matthew C. Whitby, Xiaolan Zhao

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004899

An Intracellular Transcriptomic Atlas of the Giant Coenocyte Caulerpa taxifolia

Aashish Ranjan, Brad T. Townsley, Yasunori Ichihashi, Neelima R. Sinha, Daniel H. Chitwood

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004900

Origins of Context-Dependent Gene Repression by Capicua

Marta Forés, Leiore Ajuria, Núria Samper, Sergio Astigarraga, Claudia Nieva, Rona Grossman, Sergio González-Crespo, Ze'ev Paroush, Gerardo Jiménez

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004902

The Yeast La Related Protein Slf1p Is a Key Activator of Translation during the Oxidative Stress Response

Christopher J. Kershaw, Joseph L. Costello, Lydia M. Castelli, David Talavera, William Rowe, Paul F. G. Sims, Mark P. Ashe, Simon J. Hubbard, Graham D. Pavitt, Chris M. Grant

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004903

An AP Endonuclease Functions in Active DNA Demethylation and Gene Imprinting in Arabidopsis

Yan Li, Dolores Córdoba-Cañero, Weiqiang Qian, Xiaohong Zhu, Kai Tang, Huiming Zhang, Rafael R. Ariza, Teresa Roldán-Arjona, Jian-Kang Zhu

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004905

Nicotiana Small RNA Sequences Support a Host Genome Origin of Cucumber Mosaic Virus Satellite RNA

Kiran Zahid, Jian-Hua Zhao, Neil A. Smith, Ulrike Schumann, Yuan-Yuan Fang, Elizabeth S. Dennis, Ren Zhang, Hui-Shan Guo, Ming-Bo Wang

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004906

Nur1 Dephosphorylation Confers Positive Feedback to Mitotic Exit Phosphatase Activation in Budding Yeast

Molly Godfrey, Thomas Kuilman, Frank Uhlmann

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004907

Elevated Mutation Rate during Meiosis in Saccharomyces cerevisiae

Alison Rattray, Gustavo Santoyo, Brenda Shafer, Jeffrey N. Strathern

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004910

A Re-examination of the Selection of the Sensory Organ Precursor of the Bristle Sensilla of Drosophila melanogaster

Tobias Troost, Markus Schneider, Thomas Klein

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004911

A Regulatory Hierarchy Controls the Dynamic Transcriptional Response to Extreme Oxidative Stress in Archaea

Peter D. Tonner, Adrianne M. C. Pittman, Jordan G. Gulli, Kriti Sharma, Amy K. Schmid

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004912

Genetic Mapping of MAPK-Mediated Complex Traits Across S. cerevisiae

Sebastian Treusch, Frank W. Albert, Joshua S. Bloom, Iulia E. Kotenko, Leonid Kruglyak

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004913

Transposable Elements Contribute to Activation of Maize Genes in Response to Abiotic Stress

Irina Makarevitch, Amanda J. Waters, Patrick T. West, Michelle Stitzer, Candice N. Hirsch, Jeffrey Ross-Ibarra, Nathan M. Springer

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004915

PRDM9 Drives Evolutionary Erosion of Hotspots in Mus musculus through Haplotype-Specific Initiation of Meiotic Recombination

Christopher L. Baker, Shimpei Kajita, Michael Walker, Ruth L. Saxl, Narayanan Raghupathy, Kwangbom Choi, Petko M. Petkov, Kenneth Paigen

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004916

Century-scale Methylome Stability in a Recently Diverged Arabidopsis thaliana Lineage

Jörg Hagmann, Claude Becker, Jonas Müller, Oliver Stegle, Rhonda C. Meyer, George Wang, Korbinian Schneeberger, Joffrey Fitz, Thomas Altmann, Joy Bergelson, Karsten Borgwardt, Detlef Weigel

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004920

The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway

Tomoko Uehara, Eriko Kage-Nakadai, Sawako Yoshina, Rieko Imae, Shohei Mitani

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004921

ASAR15, A cis-Acting Locus that Controls Chromosome-Wide Replication Timing and Stability of Human Chromosome 15

Nathan Donley, Leslie Smith, Mathew J. Thayer

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004923

Functional Interplay between the 53BP1-Ortholog Rad9 and the Mre11 Complex Regulates Resection, End-Tethering and Repair of a Double-Strand Break

Matteo Ferrari, Diego Dibitetto, Giuseppe De Gregorio, Vinay V. Eapen, Chetan C. Rawal, Federico Lazzaro, Michael Tsabar, Federica Marini, James E. Haber, Achille Pellicioli

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004928

Phosphorylation of Elp1 by Hrr25 Is Required for Elongator-Dependent tRNA Modification in Yeast

Wael Abdel-Fattah, Daniel Jablonowski, Rachael Di Santo, Kathrin L. Thüring, Viktor Scheidt, Alexander Hammermeister, Sara ten Have, Mark Helm, Raffael Schaffrath, Michael J. R. Stark

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004931

RecFOR Is Not Required for Pneumococcal Transformation but Together with XerS for Resolution of Chromosome Dimers Frequently Formed in the Process

Calum Johnston, Isabelle Mortier-Barrière, Chantal Granadel, Patrice Polard, Bernard Martin, Jean-Pierre Claverys

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004934

Protein Poly(ADP-ribosyl)ation Regulates Arabidopsis Immune Gene Expression and Defense Responses

Baomin Feng, Chenglong Liu, Marcos V. V. de Oliveira, Aline C. Intorne, Bo Li, Kevin Babilonia, Gonçalo A. de Souza Filho, Libo Shan, Ping He

PLOS Genetics: published January 8, 2015 | https://doi.org/10.1371/journal.pgen.1004936

Cover

An intracellular transcriptomic atlas of the giant coenocyte Caulerpa taxifolia.

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**An intracellular transcriptomic atlas of the giant coenocyte Caulerpa taxifolia.**