June 2014

Mitochondrial DNA analyses of 15 Neolithic human skeletons from the Fertile Crescent suggest that the first expansions that brought the Neolithic into Europe took place by seafaring through Cyprus and Crete.

The image shows the skeleton of a child recovered from house 4H of the Middle Euphrates Pre-pottery Neolithic site Tell Halula (7500-7300 cal BC). Skeletons were found in a seated, flexed position inside sealed pits that were excavated in the floor of the houses. These conditions might have contributed to the preservation of DNA. See Fernández et al.

Image Credit: Miquel Molist, SAPPO/UAB (Seminar on the Near East Prehistoric Archaeology/Universitat Autònoma de Barcelona)

Perspective

Inflammation: Gone with Translation

Carola G. Vinuesa, Thomas Preiss

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004442

Research Articles

Integrated Pathway-Based Approach Identifies Association between Genomic Regions at CTCF and CACNB2 and Schizophrenia

Dilafruz Juraeva, Britta Haenisch, Marc Zapatka, Josef Frank, GROUP Investigators, PSYCH-GEMS SCZ working group, Stephanie H. Witt, Thomas W. Mühleisen, Jens Treutlein, Jana Strohmaier, Sandra Meier, Franziska Degenhardt, Ina Giegling, Stephan Ripke, Markus Leber, Christoph Lange, Thomas G. Schulze, Rainald Mössner, Igor Nenadic, Heinrich Sauer, Dan Rujescu, Wolfgang Maier, Anders Børglum, Roel Ophoff, Sven Cichon, Markus M. Nöthen, Marcella Rietschel, Manuel Mattheisen, Benedikt Brors

PLOS Genetics: published June 5, 2014 | https://doi.org/10.1371/journal.pgen.1004345

Rosa26-GFP Direct Repeat (RaDR-GFP) Mice Reveal Tissue- and Age-Dependence of Homologous Recombination in Mammals In Vivo

Michelle R. Sukup-Jackson, Orsolya Kiraly, Jennifer E. Kay, Li Na, Elizabeth A. Rowland, Kelly E. Winther, Danielle N. Chow, Takafumi Kimoto, Tetsuya Matsuguchi, Vidya S. Jonnalagadda, Vilena I. Maklakova, Vijay R. Singh, Dushan N. Wadduwage, Jagath Rajapakse, Peter T. C. So, Lara S. Collier, Bevin P. Engelward

PLOS Genetics: published June 5, 2014 | https://doi.org/10.1371/journal.pgen.1004299

Microbial Succession in the Gut: Directional Trends of Taxonomic and Functional Change in a Birth Cohort of Spanish Infants

Yvonne Vallès, Alejandro Artacho, Alberto Pascual-García, Maria Loreto Ferrús, María José Gosalbes, Juan José Abellán, M. Pilar Francino

PLOS Genetics: published June 5, 2014 | https://doi.org/10.1371/journal.pgen.1004406

Deep Evolutionary Comparison of Gene Expression Identifies Parallel Recruitment of Trans-Factors in Two Independent Origins of C₄ Photosynthesis

Sylvain Aubry, Steven Kelly, Britta M. C. Kümpers, Richard D. Smith-Unna, Julian M. Hibberd

PLOS Genetics: published June 5, 2014 | https://doi.org/10.1371/journal.pgen.1004365

Glycogen Synthase Kinase (GSK) 3β Phosphorylates and Protects Nuclear Myosin 1c from Proteasome-Mediated Degradation to Activate rDNA Transcription in Early G1 Cells

Aishe A. Sarshad, Martin Corcoran, Bader Al-Muzzaini, Laura Borgonovo-Brandter, Anne Von Euler, Douglas Lamont, Neus Visa, Piergiorgio Percipalle

PLOS Genetics: published June 5, 2014 | https://doi.org/10.1371/journal.pgen.1004390

Netrins and Wnts Function Redundantly to Regulate Antero-Posterior and Dorso-Ventral Guidance in C. elegans

Naomi Levy-Strumpf, Joseph G. Culotti

PLOS Genetics: published June 5, 2014 | https://doi.org/10.1371/journal.pgen.1004381

Ancient DNA Analysis of 8000 B.C. Near Eastern Farmers Supports an Early Neolithic Pioneer Maritime Colonization of Mainland Europe through Cyprus and the Aegean Islands

Eva Fernández, Alejandro Pérez-Pérez, Cristina Gamba, Eva Prats, Pedro Cuesta, Josep Anfruns, Miquel Molist, Eduardo Arroyo-Pardo, Daniel Turbón

PLOS Genetics: published June 5, 2014 | https://doi.org/10.1371/journal.pgen.1004401

Palaeosymbiosis Revealed by Genomic Fossils of Wolbachia in a Strongyloidean Nematode

Georgios Koutsovoulos, Benjamin Makepeace, Vincent N. Tanya, Mark Blaxter

PLOS Genetics: published June 5, 2014 | https://doi.org/10.1371/journal.pgen.1004397

PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila

Kahori Shiba-Fukushima, Tsuyoshi Inoshita, Nobutaka Hattori, Yuzuru Imai

PLOS Genetics: published June 5, 2014 | https://doi.org/10.1371/journal.pgen.1004391

Genetic Background Drives Transcriptional Variation in Human Induced Pluripotent Stem Cells

Foad Rouhani, Natsuhiko Kumasaka, Miguel Cardoso de Brito, Allan Bradley, Ludovic Vallier, Daniel Gaffney

PLOS Genetics: published June 5, 2014 | https://doi.org/10.1371/journal.pgen.1004432

The Effects of Codon Context on In Vivo Translation Speed

Fabienne F. V. Chevance, Soazig Le Guyon, Kelly T. Hughes

PLOS Genetics: published June 5, 2014 | https://doi.org/10.1371/journal.pgen.1004392

Positive Feedback of NDT80 Expression Ensures Irreversible Meiotic Commitment in Budding Yeast

Dai Tsuchiya, Yang Yang, Soni Lacefield

PLOS Genetics: published June 5, 2014 | https://doi.org/10.1371/journal.pgen.1004398

OsHUS1 Facilitates Accurate Meiotic Recombination in Rice

Lixiao Che, Kejian Wang, Ding Tang, Qiaoquan Liu, Xiaojun Chen, Yafei Li, Qing Hu, Yi Shen, Hengxiu Yu, Minghong Gu, Zhukuan Cheng

PLOS Genetics: published June 5, 2014 | https://doi.org/10.1371/journal.pgen.1004405

Sequence of a Complete Chicken BG Haplotype Shows Dynamic Expansion and Contraction of Two Gene Lineages with Particular Expression Patterns

Jan Salomonsen, John A. Chattaway, Andrew C. Y. Chan, Aimée Parker, Samuel Huguet, Denise A. Marston, Sally L. Rogers, Zhiguang Wu, Adrian L. Smith, Karen Staines, Colin Butter, Patricia Riegert, Olli Vainio, Line Nielsen, Bernd Kaspers, Darren K. Griffin, Fengtang Yang, Rima Zoorob, Francois Guillemot, Charles Auffray, Stephan Beck, Karsten Skjødt, Jim Kaufman

PLOS Genetics: published June 5, 2014 | https://doi.org/10.1371/journal.pgen.1004417

Defective i⁶A37 Modification of Mitochondrial and Cytosolic tRNAs Results from Pathogenic Mutations in TRIT1 and Its Substrate tRNA

John W. Yarham, Tek N. Lamichhane, Angela Pyle, Sandy Mattijssen, Enrico Baruffini, Francesco Bruni, Claudia Donnini, Alex Vassilev, Langping He, Emma L. Blakely, Helen Griffin, Mauro Santibanez-Koref, Laurence A. Bindoff, Ileana Ferrero, Patrick F. Chinnery, Robert McFarland, Richard J. Maraia, Robert W. Taylor

PLOS Genetics: published June 5, 2014 | https://doi.org/10.1371/journal.pgen.1004424

Early Back-to-Africa Migration into the Horn of Africa

Jason A. Hodgson, Connie J. Mulligan, Ali Al-Meeri, Ryan L. Raaum

PLOS Genetics: published June 12, 2014 | https://doi.org/10.1371/journal.pgen.1004393

Genetic Determinants of Long-Term Changes in Blood Lipid Concentrations: 10-Year Follow-Up of the GLACIER Study

Tibor V. Varga, Emily Sonestedt, Dmitry Shungin, Robert W. Koivula, Göran Hallmans, Stefan A. Escher, Inês Barroso, Peter Nilsson, Olle Melander, Marju Orho-Melander, Frida Renström, Paul W. Franks

PLOS Genetics: published June 12, 2014 | https://doi.org/10.1371/journal.pgen.1004388

Loss of a Neural AMP-Activated Kinase Mimics the Effects of Elevated Serotonin on Fat, Movement, and Hormonal Secretions

Katherine A. Cunningham, Aude D. Bouagnon, Alexandre G. Barros, Lin Lin, Leandro Malard, Marco Aurélio Romano-Silva, Kaveh Ashrafi

PLOS Genetics: published June 12, 2014 | https://doi.org/10.1371/journal.pgen.1004394

JNK Controls the Onset of Mitosis in Planarian Stem Cells and Triggers Apoptotic Cell Death Required for Regeneration and Remodeling

María Almuedo-Castillo, Xenia Crespo, Florian Seebeck, Kerstin Bartscherer, Emili Salò, Teresa Adell

PLOS Genetics: published June 12, 2014 | https://doi.org/10.1371/journal.pgen.1004400

The HY5-PIF Regulatory Module Coordinates Light and Temperature Control of Photosynthetic Gene Transcription

Gabriela Toledo-Ortiz, Henrik Johansson, Keun Pyo Lee, Jordi Bou-Torrent, Kelly Stewart, Gavin Steel, Manuel Rodríguez-Concepción, Karen J. Halliday

PLOS Genetics: published June 12, 2014 | https://doi.org/10.1371/journal.pgen.1004416

The Transcription Factor TFII-I Promotes DNA Translesion Synthesis and Genomic Stability

Farjana J. Fattah, Kodai Hara, Kazi R. Fattah, Chenyi Yang, Nan Wu, Ross Warrington, David J. Chen, Pengbo Zhou, David A. Boothman, Hongtao Yu

PLOS Genetics: published June 12, 2014 | https://doi.org/10.1371/journal.pgen.1004419

Muscle Structure Influences Utrophin Expression in mdx Mice

Glen B. Banks, Ariana C. Combs, Guy L. Odom, Robert J. Bloch, Jeffrey S. Chamberlain

PLOS Genetics: published June 12, 2014 | https://doi.org/10.1371/journal.pgen.1004431

Early Embryogenesis-Specific Expression of the Rice Transposon Ping Enhances Amplification of the MITE mPing

Shota Teramoto, Takuji Tsukiyama, Yutaka Okumoto, Takatoshi Tanisaka

PLOS Genetics: published June 12, 2014 | https://doi.org/10.1371/journal.pgen.1004396

The First Endogenous Herpesvirus, Identified in the Tarsier Genome, and Novel Sequences from Primate Rhadinoviruses and Lymphocryptoviruses

Amr Aswad, Aris Katzourakis

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004332

Coordination of Wing and Whole-Body Development at Developmental Milestones Ensures Robustness against Environmental and Physiological Perturbations

Marisa M. Oliveira, Alexander W. Shingleton, Christen K. Mirth

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004408

Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity

Alexandra Kukat, Sukru Anil Dogan, Daniel Edgar, Arnaud Mourier, Christoph Jacoby, Priyanka Maiti, Jan Mauer, Christina Becker, Katharina Senft, Rolf Wibom, Alexei P. Kudin, Kjell Hultenby, Ulrich Flögel, Stephan Rosenkranz, Daniel Ricquier, Wolfram S. Kunz, Aleksandra Trifunovic

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004385

Regulatory Mechanisms That Prevent Re-initiation of DNA Replication Can Be Locally Modulated at Origins by Nearby Sequence Elements

Christopher D. Richardson, Joachim J. Li

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004358

Meiosis-Specific Cohesin Component, Stag3 Is Essential for Maintaining Centromere Chromatid Cohesion, and Required for DNA Repair and Synapsis between Homologous Chromosomes

Jessica Hopkins, Grace Hwang, Justin Jacob, Nicklas Sapp, Rick Bedigian, Kazuhiro Oka, Paul Overbeek, Steve Murray, Philip W. Jordan

PLOS Genetics: published July 3, 2014 | https://doi.org/10.1371/journal.pgen.1004413

Digital Genotyping of Macrosatellites and Multicopy Genes Reveals Novel Biological Functions Associated with Copy Number Variation of Large Tandem Repeats

Manisha Brahmachary, Audrey Guilmatre, Javier Quilez, Dan Hasson, Christelle Borel, Peter Warburton, Andrew J. Sharp

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004418

Phenotypic Dissection of Bone Mineral Density Reveals Skeletal Site Specificity and Facilitates the Identification of Novel Loci in the Genetic Regulation of Bone Mass Attainment

John P. Kemp, Carolina Medina-Gomez, Karol Estrada, Beate St Pourcain, Denise H. M. Heppe, Nicole M. Warrington, Ling Oei, Susan M. Ring, Claudia J. Kruithof, Nicholas J. Timpson, Lisa E. Wolber, Sjur Reppe, Kaare Gautvik, Elin Grundberg, Bing Ge, Bram van der Eerden, Jeroen van de Peppel, Matthew A. Hibbs, Cheryl L. Ackert-Bicknell, Kwangbom Choi, Daniel L. Koller, Michael J. Econs, Frances M. K. Williams, Tatiana Foroud, M. Carola Zillikens, Claes Ohlsson, Albert Hofman, André G. Uitterlinden, George Davey Smith, Vincent W. V. Jaddoe, Jonathan H. Tobias, Fernando Rivadeneira, David M. Evans

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004423

Identification of Late Larval Stage Developmental Checkpoints in Caenorhabditis elegans Regulated by Insulin/IGF and Steroid Hormone Signaling Pathways

Adam J. Schindler, L. Ryan Baugh, David R. Sherwood

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004426

A Novel Peptidoglycan Binding Protein Crucial for PBP1A-Mediated Cell Wall Biogenesis in Vibrio cholerae

Tobias Dörr, Hubert Lam, Laura Alvarez, Felipe Cava, Brigid M. Davis, Matthew K. Waldor

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004433

Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa Carbon Catabolite Repression

Elisabeth Sonnleitner, Udo Bläsi

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004440

The Epidermal Growth Factor Receptor Critically Regulates Endometrial Function during Early Pregnancy

Michael J. Large, Margeaux Wetendorf, Rainer B. Lanz, Sean M. Hartig, Chad J. Creighton, Michael A. Mancini, Ertug Kovanci, Kuo-Fen Lee, David W. Threadgill, John P. Lydon, Jae-Wook Jeong, Francesco J. DeMayo

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004451

CPF-Associated Phosphatase Activity Opposes Condensin-Mediated Chromosome Condensation

Vincent Vanoosthuyse, Pénélope Legros, Sjaak J. A. van der Sar, Gaël Yvert, Kenji Toda, Thierry Le Bihan, Yoshinori Watanabe, Kevin Hardwick, Pascal Bernard

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004415

Introgression from Domestic Goat Generated Variation at the Major Histocompatibility Complex of Alpine Ibex

Christine Grossen, Lukas Keller, Iris Biebach, The International Goat Genome Consortium, Daniel Croll

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004438

An Operon of Three Transcriptional Regulators Controls Horizontal Gene Transfer of the Integrative and Conjugative Element ICEclc in Pseudomonas knackmussii B13

Nicolas Pradervand, Sandra Sulser, François Delavat, Ryo Miyazaki, Iker Lamas, Jan Roelof van der Meer

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004441

Transcriptional Control of Steroid Biosynthesis Genes in the Drosophila Prothoracic Gland by Ventral Veins Lacking and Knirps

E. Thomas Danielsen, Morten E. Moeller, Elad Dorry, Tatsuya Komura-Kawa, Yoshinori Fujimoto, Jesper T. Troelsen, Rachel Herder, Michael B. O'Connor, Ryusuke Niwa, Kim F. Rewitz

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004343

Sgo1 Regulates Both Condensin and Ipl1/Aurora B to Promote Chromosome Biorientation

Karolina Peplowska, Andreas U. Wallek, Zuzana Storchova

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004411

The EJC Binding and Dissociating Activity of PYM Is Regulated in Drosophila

Sanjay Ghosh, Ales Obrdlik, Virginie Marchand, Anne Ephrussi

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004455

Transport of Magnesium by a Bacterial Nramp-Related Gene

Jung-Ho Shin, Catherine A. Wakeman, Jonathan R. Goodson, Dmitry A. Rodionov, Benjamin G. Freedman, Ryan S. Senger, Wade C. Winkler

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004429

Pervasive Divergence of Transcriptional Gene Regulation in Caenorhabditis Nematodes

Antoine Barrière, Ilya Ruvinsky

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004435

Souffle/Spastizin Controls Secretory Vesicle Maturation during Zebrafish Oogenesis

Palsamy Kanagaraj, Amandine Gautier-Stein, Dietmar Riedel, Christoph Schomburg, Joan Cerdà, Nadine Vollack, Roland Dosch

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004449

Recombination Accelerates Adaptation on a Large-Scale Empirical Fitness Landscape in HIV-1

Danesh Moradigaravand, Roger Kouyos, Trevor Hinkley, Mojgan Haddad, Christos J. Petropoulos, Jan Engelstädter, Sebastian Bonhoeffer

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004439

Translational Regulation of Specific mRNAs Controls Feedback Inhibition and Survival during Macrophage Activation

Johanna Schott, Sonja Reitter, Janine Philipp, Katharina Haneke, Heiner Schäfer, Georg Stoecklin

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004368

Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency

Tomoyuki Sasaki, Shanshan Lian, Jie Qi, Peter E. Bayliss, Christopher E. Carr, Jennifer L. Johnson, Sujay Guha, Patrick Kobler, Sergio D. Catz, Matthew Gill, Kailiang Jia, Daniel J. Klionsky, Shuji Kishi

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004409

Background Selection as Baseline for Nucleotide Variation across the Drosophila Genome

Josep M. Comeron

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004434

ATRA-Induced Cellular Differentiation and CD38 Expression Inhibits Acquisition of BCR-ABL Mutations for CML Acquired Resistance

Zhiqiang Wang, Zheng Liu, Xiwei Wu, Su Chu, Jinhui Wang, Hongfeng Yuan, Mendel Roth, Yate-Ching Yuan, Ravi Bhatia, WenYong Chen

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004414

BLMP-1/Blimp-1 Regulates the Spatiotemporal Cell Migration Pattern in C. elegans

Tsai-Fang Huang, Chun-Yi Cho, Yi-Ting Cheng, Jheng-Wei Huang, Yun-Zhe Wu, Athena Yi-Chun Yeh, Kiyoji Nishiwaki, Shih-Chung Chang, Yi-Chun Wu

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004428

Hecate/Grip2a Acts to Reorganize the Cytoskeleton in the Symmetry-Breaking Event of Embryonic Axis Induction

Xiaoyan Ge, Danielle Grotjahn, Elaine Welch, Jamie Lyman-Gingerich, Christiana Holguin, Eva Dimitrova, Elliot W. Abrams, Tripti Gupta, Florence L. Marlow, Taijiro Yabe, Anna Adler, Mary C. Mullins, Francisco Pelegri

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004422

Speciation and Introgression between Mimulus nasutus and Mimulus guttatus

Yaniv Brandvain, Amanda M. Kenney, Lex Flagel, Graham Coop, Andrea L. Sweigart

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004410

The POU Factor Ventral Veins Lacking/Drifter Directs the Timing of Metamorphosis through Ecdysteroid and Juvenile Hormone Signaling

CeCe Cheng, Amy Ko, Leila Chaieb, Takashi Koyama, Prioty Sarwar, Christen K. Mirth, Wendy A. Smith, Yuichiro Suzuki

PLOS Genetics: published June 19, 2014 | https://doi.org/10.1371/journal.pgen.1004425

Accurate, Model-Based Tuning of Synthetic Gene Expression Using Introns in S. cerevisiae

Ido Yofe, Zohar Zafrir, Rachel Blau, Maya Schuldiner, Tamir Tuller, Ehud Shapiro, Tuval Ben-Yehezkel

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004407

Ex Uno Plures: Clonal Reinforcement Drives Evolution of a Simple Microbial Community

Margie Kinnersley, Jared Wenger, Evgueny Kroll, Julian Adams, Gavin Sherlock, Frank Rosenzweig

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004430

N-WASP Is Required for Structural Integrity of the Blood-Testis Barrier

Xiang Xiao, Dolores D. Mruk, Elizabeth I. Tang, R'ada Massarwa, Ka Wai Mok, Nan Li, Chris K. C. Wong, Will M. Lee, Scott B. Snapper, Ben-Zion Shilo, Eyal D. Schejter, C. Yan Cheng

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004447

The Rim15-Endosulfine-PP2A^Cdc55 Signalling Module Regulates Entry into Gametogenesis and Quiescence via Distinct Mechanisms in Budding Yeast

Sourav Sarkar, Jacob Z. Dalgaard, Jonathan B. A. Millar, Prakash Arumugam

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004456

Abnormal Type I Collagen Post-translational Modification and Crosslinking in a Cyclophilin B KO Mouse Model of Recessive Osteogenesis Imperfecta

Wayne A. Cabral, Irina Perdivara, MaryAnn Weis, Masahiko Terajima, Angela R. Blissett, Weizhong Chang, Joseph E. Perosky, Elena N. Makareeva, Edward L. Mertz, Sergey Leikin, Kenneth B. Tomer, Kenneth M. Kozloff, David R. Eyre, Mitsuo Yamauchi, Joan C. Marini

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004465

Rasa3 Controls Megakaryocyte Rap1 Activation, Integrin Signaling and Differentiation into Proplatelet

Patricia Molina-Ortiz, Séléna Polizzi, Eve Ramery, Stéphanie Gayral, Céline Delierneux, Cécile Oury, Shintaro Iwashita, Stéphane Schurmans

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004420

Reviving the Dead: History and Reactivation of an Extinct L1

Lei Yang, John Brunsfeld, LuAnn Scott, Holly Wichman

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004395

Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4⁺ Effector Memory T Cells

Xinli Hu, Hyun Kim, Towfique Raj, Patrick J. Brennan, Gosia Trynka, Nikola Teslovich, Kamil Slowikowski, Wei-Min Chen, Suna Onengut, Clare Baecher-Allan, Philip L. De Jager, Stephen S. Rich, Barbara E. Stranger, Michael B. Brenner, Soumya Raychaudhuri

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004404

Caspase Inhibition in Select Olfactory Neurons Restores Innate Attraction Behavior in Aged Drosophila

Takahiro Chihara, Aki Kitabayashi, Michie Morimoto, Ken-ichi Takeuchi, Kaoru Masuyama, Ayako Tonoki, Ronald L. Davis, Jing W. Wang, Masayuki Miura

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004437

Mouse Y-Linked Zfy1 and Zfy2 Are Expressed during the Male-Specific Interphase between Meiosis I and Meiosis II and Promote the 2^nd Meiotic Division

Nadège Vernet, Shantha K. Mahadevaiah, Yasuhiro Yamauchi, Fanny Decarpentrie, Michael J. Mitchell, Monika A. Ward, Paul S. Burgoyne

PLOS Genetics: published June 26, 2014 | https://doi.org/10.1371/journal.pgen.1004444

Corrections

Correction: The Challenges of Mitochondrial Replacement

The PLOS Genetics Staff

PLOS Genetics: published June 2, 2014 | https://doi.org/10.1371/journal.pgen.1004472

Correction: Differential Effects of Collagen Prolyl 3-Hydroxylation on Skeletal Tissues

The PLOS Genetics Staff

PLOS Genetics: published June 3, 2014 | https://doi.org/10.1371/journal.pgen.1004473

Correction: NBR1-Mediated Selective Autophagy Targets Insoluble Ubiquitinated Protein Aggregates in Plant Stress Responses

The PLOS Genetics Staff

PLOS Genetics: published June 6, 2014 | https://doi.org/10.1371/journal.pgen.1004477

Correction: E3 Ubiquitin Ligase CHIP and NBR1-Mediated Selective Autophagy Protect Additively against Proteotoxicity in Plant Stress Responses

The PLOS Genetics Staff

PLOS Genetics: published June 6, 2014 | https://doi.org/10.1371/journal.pgen.1004478

Correction: Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity

The PLOS Genetics Staff

PLOS Genetics: published June 27, 2014 | https://doi.org/10.1371/journal.pgen.1004535

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First farmers arrived to the European continent by sea.

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