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July 2013

A horizontal section of Arabidopsis shoot apex (round magenta region at the center) and several leaf primordia (triangular magenta and green regions) generated from the apex. Green and magenta colors are markers of the abaxial and the adaxial cell fates, respectively. Each leaf primordium shows both markers, but the green-to-magenta areal ratio is higher in young primordia (near the apex) than in older primordia (farther from the apex). This indicates that leaf cell fate shifts from the abaxial to the adaxial, according to the leaf development. See Tameshige et al.

Image Credit: Toshiaki Tameshige

Research Articles

Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry

Shafqat Ahmad, Gull Rukh, Tibor V. Varga, Ashfaq Ali, Azra Kurbasic, Dmitry Shungin, Ulrika Ericson, Robert W. Koivula, Audrey Y. Chu, Lynda M. Rose, Andrea Ganna, Qibin Qi, Alena Stančáková, Camilla H. Sandholt, Cathy E. Elks, Gary Curhan, Majken K. Jensen, Rulla M. Tamimi, Kristine H. Allin, Torben Jørgensen, Soren Brage, Claudia Langenberg, Mette Aadahl, Niels Grarup, Allan Linneberg, Guillaume Paré, InterAct Consortium, DIRECT Consortium, Patrik K. E. Magnusson, Nancy L. Pedersen, Michael Boehnke, Anders Hamsten, Karen L. Mohlke, Louis T. Pasquale, Oluf Pedersen, Robert A. Scott, Paul M. Ridker, Erik Ingelsson, Markku Laakso, Torben Hansen, Lu Qi, Nicholas J. Wareham, Daniel I. Chasman, Göran Hallmans, Frank B. Hu, Frida Renström, Marju Orho-Melander, Paul W. Franks

RBM5 Is a Male Germ Cell Splicing Factor and Is Required for Spermatid Differentiation and Male Fertility

Moira K. O'Bryan, Brett J. Clark, Eileen A. McLaughlin, Rebecca J. D'Sylva, Liza O'Donnell, Jacqueline A. Wilce, Jessie Sutherland, Anne E. O'Connor, Belinda Whittle, Christopher C. Goodnow, Christopher J. Ormandy, Duangporn Jamsai

Reassembly of Nucleosomes at the MLH1 Promoter Initiates Resilencing Following Decitabine Exposure

Luke B. Hesson, Vibha Patil, Mathew A. Sloane, Andrea C. Nunez, Jia Liu, John E. Pimanda, Robyn L. Ward

Oxidative Stress and Replication-Independent DNA Breakage Induced by Arsenic in Saccharomyces cerevisiae

Ireneusz Litwin, Tomasz Bocer, Dorota Dziadkowiec, Robert Wysocki

A Dual Role for SOX10 in the Maintenance of the Postnatal Melanocyte Lineage and the Differentiation of Melanocyte Stem Cell Progenitors

Melissa L. Harris, Kristina Buac, Olga Shakhova, Ramin M. Hakami, Michael Wegner, Lukas Sommer, William J. Pavan

The Role of Interruptions in polyQ in the Pathology of SCA1

Rajesh P. Menon, Suran Nethisinghe, Serena Faggiano, Tommaso Vannocci, Human Rezaei, Sally Pemble, Mary G. Sweeney, Nicholas W. Wood, Mary B. Davis, Annalisa Pastore, Paola Giunti

Hepatocyte Growth Factor Signaling in Intrapancreatic Ductal Cells Drives Pancreatic Morphogenesis

Ryan M. Anderson, Marion Delous, Justin A. Bosch, Lihua Ye, Morgan A. Robertson, Daniel Hesselson, Didier Y. R. Stainier

Dietary Restriction Induced Longevity Is Mediated by Nuclear Receptor NHR-62 in Caenorhabditis elegans

Bree N. Heestand, Yidong Shen, Wei Liu, Daniel B. Magner, Nadia Storm, Caroline Meharg, Bianca Habermann, Adam Antebi

The bHLH Subgroup IIId Factors Negatively Regulate Jasmonate-Mediated Plant Defense and Development

Susheng Song, Tiancong Qi, Meng Fan, Xing Zhang, Hua Gao, Huang Huang, Dewei Wu, Hongwei Guo, Daoxin Xie

Pattern Dynamics in Adaxial-Abaxial Specific Gene Expression Are Modulated by a Plastid Retrograde Signal during Arabidopsis thaliana Leaf Development

Toshiaki Tameshige, Hironori Fujita, Keiro Watanabe, Koichi Toyokura, Maki Kondo, Kiyoshi Tatematsu, Noritaka Matsumoto, Ryuji Tsugeki, Masayoshi Kawaguchi, Mikio Nishimura, Kiyotaka Okada

A Moonlighting Enzyme Links Escherichia coli Cell Size with Central Metabolism

Norbert S. Hill, Paul J. Buske, Yue Shi, Petra Anne Levin

Mechanisms of Protein Sequence Divergence and Incompatibility

Alon Wellner, Maria Raitses Gurevich, Dan S. Tawfik

Recombination Dynamics of a Human Y-Chromosomal Palindrome: Rapid GC-Biased Gene Conversion, Multi-kilobase Conversion Tracts, and Rare Inversions

Pille Hallast, Patricia Balaresque, Georgina R. Bowden, Stéphane Ballereau, Mark A. Jobling

The Mating Competence of Geographically Diverse Leishmania major Strains in Their Natural and Unnatural Sand Fly Vectors

Ehud Inbar, Natalia S. Akopyants, Melanie Charmoy, Audrey Romano, Phillip Lawyer, Dia-Eldin A. Elnaiem, Florence Kauffmann, Mourad Barhoumi, Michael Grigg, Katherine Owens, Michael Fay, Deborah E. Dobson, Jahangheer Shaik, Stephen M. Beverley, David Sacks

Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4

Harinder Manku, Carl D. Langefeld, Sandra G. Guerra, Talat H. Malik, Marta Alarcon-Riquelme, Juan-Manuel Anaya, Sang-Cheol Bae, Susan A. Boackle, Elizabeth E. Brown, Lindsey A. Criswell, Barry I. Freedman, Patrick M. Gaffney, Peter A. Gregersen, Joel M. Guthridge, Sang-Hoon Han, John B. Harley, Chaim O. Jacob, Judith A. James, Diane L. Kamen, Kenneth M. Kaufman, Jennifer A. Kelly, Javier Martin, Joan T. Merrill, Kathy L. Moser, Timothy B. Niewold, So-Yeon Park, Bernardo A. Pons-Estel, Amr H. Sawalha, R. Hal Scofield, Nan Shen, Anne M. Stevens, Celi Sun, Gary S. Gilkeson, Jeff C. Edberg, Robert P. Kimberly, Swapan K. Nath, Betty P. Tsao, Tim J. Vyse

Role of CTCF Protein in Regulating FMR1 Locus Transcription

Stella Lanni, Martina Goracci, Loredana Borrelli, Giorgia Mancano, Pietro Chiurazzi, Umberto Moscato, Fabrizio Ferrè, Manuela Helmer-Citterich, Elisabetta Tabolacci, Giovanni Neri

Exquisite Light Sensitivity of Drosophila melanogaster Cryptochrome

Pooja Vinayak, Jamie Coupar, S. Emile Hughes, Preeya Fozdar, Jack Kilby, Emma Garren, Taishi Yoshii, Jay Hirsh

The BTB-zinc Finger Transcription Factor Abrupt Acts as an Epithelial Oncogene in Drosophila melanogaster through Maintaining a Progenitor-like Cell State

Nezaket Turkel, Virender K. Sahota, Jessica E. Bolden, Karen R. Goulding, Karen Doggett, Lee F. Willoughby, Enrique Blanco, Enrique Martin-Blanco, Montserrat Corominas, Jason Ellul, Toshiro Aigaki, Helena E. Richardson, Anthony M. Brumby

Genomic Analysis of Natural Selection and Phenotypic Variation in High-Altitude Mongolians

Jinchuan Xing, Tana Wuren, Tatum S. Simonson, W. Scott Watkins, David J. Witherspoon, Wilfred Wu, Ga Qin, Chad D. Huff, Lynn B. Jorde, Ri-Li Ge

Independent Evolution of Transcriptional Inactivation on Sex Chromosomes in Birds and Mammals

Alexandra M. Livernois, Shafagh A. Waters, Janine E. Deakin, Jennifer A. Marshall Graves, Paul D. Waters

Defective Repair of Oxidative Base Lesions by the DNA Glycosylase Nth1 Associates with Multiple Telomere Defects

Haritha Vallabhaneni, Nathan O'Callaghan, Julia Sidorova, Yie Liu

A Network of HMG-box Transcription Factors Regulates Sexual Cycle in the Fungus Podospora anserina

Jinane Ait Benkhali, Evelyne Coppin, Sylvain Brun, Leonardo Peraza-Reyes, Tom Martin, Christina Dixelius, Noureddine Lazar, Herman van Tilbeurgh, Robert Debuchy

Stepwise Activation of the ATR Signaling Pathway upon Increasing Replication Stress Impacts Fragile Site Integrity

Stéphane Koundrioukoff, Sandra Carignon, Hervé Técher, Anne Letessier, Olivier Brison, Michelle Debatisse

Genome-Wide Association Mapping in Dogs Enables Identification of the Homeobox Gene, NKX2-8, as a Genetic Component of Neural Tube Defects in Humans

Noa Safra, Alexander G. Bassuk, Polly J. Ferguson, Miriam Aguilar, Rochelle L. Coulson, Nicholas Thomas, Peta L. Hitchens, Peter J. Dickinson, Karen M. Vernau, Zena T. Wolf, Danika L. Bannasch

Modification of tRNALysUUU by Elongator Is Essential for Efficient Translation of Stress mRNAs

Jorge Fernández-Vázquez, Itzel Vargas-Pérez, Miriam Sansó, Karin Buhne, Mercè Carmona, Esther Paulo, Damien Hermand, Miguel Rodríguez-Gabriel, José Ayté, Sebastian Leidel, Elena Hidalgo

Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus

Clint L. Miller, D. Ryan Anderson, Ramendra K. Kundu, Azad Raiesdana, Sylvia T. Nürnberg, Roxanne Diaz, Karen Cheng, Nicholas J. Leeper, Chung-Hsing Chen, I-Shou Chang, Eric E. Schadt, Chao Agnes Hsiung, Themistocles L. Assimes, Thomas Quertermous

Yeast Pol4 Promotes Tel1-Regulated Chromosomal Translocations

Jose F. Ruiz, Benjamin Pardo, Guillermo Sastre-Moreno, Andrés Aguilera, Luis Blanco

NTRK3 Is a Potential Tumor Suppressor Gene Commonly Inactivated by Epigenetic Mechanisms in Colorectal Cancer

Yanxin Luo, Andrew M. Kaz, Samornmas Kanngurn, Piri Welsch, Shelli M. Morris, Jianping Wang, James D. Lutterbaugh, Sanford D. Markowitz, William M. Grady

Odoriferous Defensive Stink Gland Transcriptome to Identify Novel Genes Necessary for Quinone Synthesis in the Red Flour Beetle, Tribolium castaneum

Jianwei Li, Sabrina Lehmann, Bernhard Weißbecker, Irene Ojeda Naharros, Stefan Schütz, Gerrit Joop, Ernst A. Wimmer

Prediction of Complex Human Traits Using the Genomic Best Linear Unbiased Predictor

Gustavo de los Campos, Ana I. Vazquez, Rohan Fernando, Yann C. Klimentidis, Daniel Sorensen

ENU-induced Mutation in the DNA-binding Domain of KLF3 Reveals Important Roles for KLF3 in Cardiovascular Development and Function in Mice

Lois Kelsey, Ann M. Flenniken, Dawei Qu, Alister P. W. Funnell, Richard Pearson, Yu-Qing Zhou, Irina Voronina, Zorana Berberovic, Geoffrey Wood, Susan Newbigging, Edward S. Weiss, Michael Wong, Ivan Quach, S. Y. Sandy Yeh, Ashish R. Deshwar, Ian C. Scott, Colin McKerlie, Mark Henkelman, Peter Backx, Jeremy Simpson, Lucy Osborne, Janet Rossant, Merlin Crossley, Benoit Bruneau, S. Lee Adamson

The Conserved ADAMTS-like Protein Lonely heart Mediates Matrix Formation and Cardiac Tissue Integrity

Maik Drechsler, Ariane C. Schmidt, Heiko Meyer, Achim Paululat

Bacterial Adaptation through Loss of Function

Alison K. Hottes, Peter L. Freddolino, Anupama Khare, Zachary N. Donnell, Julia C. Liu, Saeed Tavazoie

The C. elegans cGMP-Dependent Protein Kinase EGL-4 Regulates Nociceptive Behavioral Sensitivity

Michelle C. Krzyzanowski, Chantal Brueggemann, Meredith J. Ezak, Jordan F. Wood, Kerry L. Michaels, Christopher A. Jackson, Bi-Tzen Juang, Kimberly D. Collins, Michael C. Yu, Noelle D. L'Etoile, Denise M. Ferkey

Female Behaviour Drives Expression and Evolution of Gustatory Receptors in Butterflies

Adriana D. Briscoe, Aide Macias-Muñoz, Krzysztof M. Kozak, James R. Walters, Furong Yuan, Gabriel A. Jamie, Simon H. Martin, Kanchon K. Dasmahapatra, Laura C. Ferguson, James Mallet, Emmanuelle Jacquin-Joly, Chris D. Jiggins

Gene Set Signature of Reversal Reaction Type I in Leprosy Patients

Marianna Orlova, Aurélie Cobat, Nguyen Thu Huong, Nguyen Ngoc Ba, Nguyen Van Thuc, John Spencer, Yohann Nédélec, Luis Barreiro, Vu Hong Thai, Laurent Abel, Alexandre Alcaïs, Erwin Schurr

miR-133a Regulates Adipocyte Browning In Vivo

Weiyi Liu, Pengpeng Bi, Tizhong Shan, Xin Yang, Hang Yin, Yong-Xu Wang, Ning Liu, Michael A. Rudnicki, Shihuan Kuang

Gata4 Is Required for Formation of the Genital Ridge in Mice

Yueh-Chiang Hu, Leah M. Okumura, David C. Page

Genome-scale Co-evolutionary Inference Identifies Functions and Clients of Bacterial Hsp90

Maximilian O. Press, Hui Li, Nicole Creanza, Günter Kramer, Christine Queitsch, Victor Sourjik, Elhanan Borenstein

SLC26A4 Targeted to the Endolymphatic Sac Rescues Hearing and Balance in Slc26a4 Mutant Mice

Xiangming Li, Joel D. Sanneman, Donald G. Harbidge, Fei Zhou, Taku Ito, Raoul Nelson, Nicolas Picard, Régine Chambrey, Dominique Eladari, Tracy Miesner, Andrew J. Griffith, Daniel C. Marcus, Philine Wangemann

Budding Yeast Greatwall and Endosulfines Control Activity and Spatial Regulation of PP2ACdc55 for Timely Mitotic Progression

Maria Angeles Juanes, Rita Khoueiry, Thomas Kupka, Anna Castro, Ingrid Mudrak, Egon Ogris, Thierry Lorca, Simonetta Piatti

Mapping of PARK2 and PACRG Overlapping Regulatory Region Reveals LD Structure and Functional Variants in Association with Leprosy in Unrelated Indian Population Groups

Rupali Chopra, Shafat Ali, Amit K. Srivastava, Shweta Aggarwal, Bhupender Kumar, Siddharth Manvati, Ponnusamy Kalaiarasan, Mamta Jena, Vijay K. Garg, Sambit N. Bhattacharya, Rameshwar N. K. Bamezai

Alu Elements in ANRIL Non-Coding RNA at Chromosome 9p21 Modulate Atherogenic Cell Functions through Trans-Regulation of Gene Networks

Lesca M. Holdt, Steve Hoffmann, Kristina Sass, David Langenberger, Markus Scholz, Knut Krohn, Knut Finstermeier, Anika Stahringer, Wolfgang Wilfert, Frank Beutner, Stephan Gielen, Gerhard Schuler, Gabor Gäbel, Hendrik Bergert, Ingo Bechmann, Peter F. Stadler, Joachim Thiery, Daniel Teupser

Effective Blocking of the White Enhancer Requires Cooperation between Two Main Mechanisms Suggested for the Insulator Function

Olga Kyrchanova, Oksana Maksimenko, Viacheslav Stakhov, Tatyana Ivlieva, Alexander Parshikov, Vasily M. Studitsky, Pavel Georgiev

Monopolin Subunit Csm1 Associates with MIND Complex to Establish Monopolar Attachment of Sister Kinetochores at Meiosis I

Sourav Sarkar, Rajesh T. Shenoy, Jacob Z. Dalgaard, Louise Newnham, Eva Hoffmann, Jonathan B. A. Millar, Prakash Arumugam

Histone Methyltransferase DOT1L Drives Recovery of Gene Expression after a Genotoxic Attack

Valentyn Oksenych, Alexander Zhovmer, Salim Ziani, Pierre-Olivier Mari, Jitka Eberova, Tiziana Nardo, Miria Stefanini, Giuseppina Giglia-Mari, Jean-Marc Egly, Frédéric Coin