June 2013

Budding Yeast ATM/ATR Control Meiotic Double-Strand Break (DSB) Levels by Down-Regulating Rec114, an Essential Component of the DSB-machinery

Jesús A. Carballo, Silvia Panizza, Maria Elisabetta Serrentino, Anthony L. Johnson, Marco Geymonat, Valérie Borde, Franz Klein, Rita S. Cha

PLOS Genetics: published June 27, 2013 | https://doi.org/10.1371/journal.pgen.1003545

The Identification of Trans-acting Factors That Regulate the Expression of GDF5 via the Osteoarthritis Susceptibility SNP rs143383

Catherine M. Syddall, Louise N. Reynard, David A. Young, John Loughlin

PLOS Genetics: published June 27, 2013 | https://doi.org/10.1371/journal.pgen.1003557

A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue

Tina Rönn, Petr Volkov, Cajsa Davegårdh, Tasnim Dayeh, Elin Hall, Anders H. Olsson, Emma Nilsson, Åsa Tornberg, Marloes Dekker Nitert, Karl-Fredrik Eriksson, Helena A. Jones, Leif Groop, Charlotte Ling

PLOS Genetics: published June 27, 2013 | https://doi.org/10.1371/journal.pgen.1003572

DNA Methylation Restricts Lineage-specific Functions of Transcription Factor Gata4 during Embryonic Stem Cell Differentiation

Masaaki Oda, Yuichi Kumaki, Masaki Shigeta, Lars Martin Jakt, Chisa Matsuoka, Akiko Yamagiwa, Hitoshi Niwa, Masaki Okano

PLOS Genetics: published June 27, 2013 | https://doi.org/10.1371/journal.pgen.1003574

Environmental Dependence of Genetic Constraint

Marjon G. J. de Vos, Frank J. Poelwijk, Nico Battich, Joseph D. T. Ndika, Sander J. Tans

PLOS Genetics: published June 27, 2013 | https://doi.org/10.1371/journal.pgen.1003580

Drosophila Distal-less and Rotund Bind a Single Enhancer Ensuring Reliable and Robust bric-a-brac2 Expression in Distinct Limb Morphogenetic Fields

Aissette Baanannou, Luis Humberto Mojica-Vazquez, Gaylord Darras, Jean-Louis Couderc, David L. Cribbs, Muriel Boube, Henri-Marc Bourbon

PLOS Genetics: published June 27, 2013 | https://doi.org/10.1371/journal.pgen.1003581

Heritable Change Caused by Transient Transcription Errors

Alasdair J. E. Gordon, Dominik Satory, Jennifer A. Halliday, Christophe Herman

PLOS Genetics: published June 27, 2013 | https://doi.org/10.1371/journal.pgen.1003595

Multiplexin Promotes Heart but Not Aorta Morphogenesis by Polarized Enhancement of Slit/Robo Activity at the Heart Lumen

Nofar Harpaz, Elly Ordan, Karen Ocorr, Rolf Bodmer, Talila Volk

PLOS Genetics: published June 27, 2013 | https://doi.org/10.1371/journal.pgen.1003597

Saccharomyces cerevisiae DNA Ligase IV Supports Imprecise End Joining Independently of Its Catalytic Activity

Kishore K. Chiruvella, Zhuobin Liang, Shanda R. Birkeland, Venkatesha Basrur, Thomas E. Wilson

PLOS Genetics: published June 27, 2013 | https://doi.org/10.1371/journal.pgen.1003599

Latent Effects of Hsp90 Mutants Revealed at Reduced Expression Levels

Li Jiang, Parul Mishra, Ryan T. Hietpas, Konstantin B. Zeldovich, Daniel N. A. Bolon

PLOS Genetics: published June 27, 2013 | https://doi.org/10.1371/journal.pgen.1003600

Transcriptome-Wide Mapping of 5-methylcytidine RNA Modifications in Bacteria, Archaea, and Yeast Reveals m⁵C within Archaeal mRNAs

Sarit Edelheit, Schraga Schwartz, Maxwell R. Mumbach, Omri Wurtzel, Rotem Sorek

PLOS Genetics: published June 27, 2013 | https://doi.org/10.1371/journal.pgen.1003602

From Many, One: Genetic Control of Prolificacy during Maize Domestication

David M. Wills, Clinton J. Whipple, Shohei Takuno, Lisa E. Kursel, Laura M. Shannon, Jeffrey Ross-Ibarra, John F. Doebley

PLOS Genetics: published June 27, 2013 | https://doi.org/10.1371/journal.pgen.1003604

Neuronal Target Identification Requires AHA-1-Mediated Fine-Tuning of Wnt Signaling in C. elegans

Jingyan Zhang, Xia Li, Angela R. Jevince, Liying Guan, Jiaming Wang, David H. Hall, Xun Huang, Mei Ding

PLOS Genetics: published June 27, 2013 | https://doi.org/10.1371/journal.pgen.1003618

The Genome of Tolypocladium inflatum: Evolution, Organization, and Expression of the Cyclosporin Biosynthetic Gene Cluster

Kathryn E. Bushley, Rajani Raja, Pankaj Jaiswal, Jason S. Cumbie, Mariko Nonogaki, Alexander E. Boyd, C. Alisha Owensby, Brian J. Knaus, Justin Elser, Daniel Miller, Yanming Di, Kerry L. McPhail, Joseph W. Spatafora

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003496

Integrated Transcriptomic and Epigenomic Analysis of Primary Human Lung Epithelial Cell Differentiation

Crystal N. Marconett, Beiyun Zhou, Megan E. Rieger, Suhaida A. Selamat, Mickael Dubourd, Xiaohui Fang, Sean K. Lynch, Theresa Ryan Stueve, Kimberly D. Siegmund, Benjamin P. Berman, Zea Borok, Ite A. Laird-Offringa

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003513

The NADPH Metabolic Network Regulates Human αB-crystallin Cardiomyopathy and Reductive Stress in Drosophila melanogaster

Heng B. Xie, Anthony Cammarato, Namakkal S. Rajasekaran, Huali Zhang, Jennifer A. Suggs, Ho-Chen Lin, Sanford I. Bernstein, Ivor J. Benjamin, Kent G. Golic

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003544

Distinct and Atypical Intrinsic and Extrinsic Cell Death Pathways between Photoreceptor Cell Types upon Specific Ablation of Ranbp2 in Cone Photoreceptors

Kyoung-in Cho, MdEmdadul Haque, Jessica Wang, Minzhong Yu, Ying Hao, Sunny Qiu, Indulekha C. L. Pillai, Neal S. Peachey, Paulo A. Ferreira

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003555

Survival Response to Increased Ceramide Involves Metabolic Adaptation through Novel Regulators of Glycolysis and Lipolysis

Niraj K. Nirala, Motiur Rahman, Stanley M. Walls, Alka Singh, Lihua Julie Zhu, Takeshi Bamba, Eiichiro Fukusaki, Sargur M. Srideshikan, Greg L. Harris, Y. Tony Ip, Rolf Bodmer, Usha R. Acharya

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003556

Cohesin and Polycomb Proteins Functionally Interact to Control Transcription at Silenced and Active Genes

Cheri A. Schaaf, Ziva Misulovin, Maria Gause, Amanda Koenig, David W. Gohara, Audrey Watson, Dale Dorsett

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003560

Disturbed Local Auxin Homeostasis Enhances Cellular Anisotropy and Reveals Alternative Wiring of Auxin-ethylene Crosstalk in Brachypodium distachyon Seminal Roots

David Pacheco-Villalobos, Martial Sankar, Karin Ljung, Christian S. Hardtke

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003564

Genome-scale Analysis of Escherichia coli FNR Reveals Complex Features of Transcription Factor Binding

Kevin S. Myers, Huihuang Yan, Irene M. Ong, Dongjun Chung, Kun Liang, Frances Tran, Sündüz Keleş, Robert Landick, Patricia J. Kiley

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003565

Horizontally Acquired Glycosyltransferase Operons Drive Salmonellae Lipopolysaccharide Diversity

Mark R. Davies, Sarah E. Broadbent, Simon R. Harris, Nicholas R. Thomson, Marjan W. van der Woude

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003568

Pervasive Transcription of the Human Genome Produces Thousands of Previously Unidentified Long Intergenic Noncoding RNAs

Matthew J. Hangauer, Ian W. Vaughn, Michael T. McManus

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003569

Integrative “Omics”-Approach Discovers Dynamic and Regulatory Features of Bacterial Stress Responses

Bork A. Berghoff, Anne Konzer, Nils N. Mank, Mario Looso, Tom Rische, Konrad U. Förstner, Marcus Krüger, Gabriele Klug

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003576

ABI4 Regulates Primary Seed Dormancy by Regulating the Biogenesis of Abscisic Acid and Gibberellins in Arabidopsis

Kai Shu, Huawei Zhang, Shengfu Wang, Mingluan Chen, Yaorong Wu, Sanyuan Tang, Chunyan Liu, Yuqi Feng, Xiaofeng Cao, Qi Xie

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003577

Evidence for Two Different Regulatory Mechanisms Linking Replication and Segregation of Vibrio cholerae Chromosome II

Tatiana Venkova-Canova, Jong Hwan Baek, Peter C. FitzGerald, Melanie Blokesch, Dhruba K. Chattoraj

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003579

Loss of Catalytically Inactive Lipid Phosphatase Myotubularin-related Protein 12 Impairs Myotubularin Stability and Promotes Centronuclear Myopathy in Zebrafish

Vandana A. Gupta, Karim Hnia, Laura L. Smith, Stacey R. Gundry, Jessica E. McIntire, Junko Shimazu, Jessica R. Bass, Ethan A. Talbot, Leonela Amoasii, Nathaniel E. Goldman, Jocelyn Laporte, Alan H. Beggs

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003583

Comprehensive High-Resolution Analysis of the Role of an Arabidopsis Gene Family in RNA Editing

Stéphane Bentolila, Julyun Oh, Maureen R. Hanson, Robert Bukowski

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003584

Extensive Intra-Kingdom Horizontal Gene Transfer Converging on a Fungal Fructose Transporter Gene

Marco A. Coelho, Carla Gonçalves, José Paulo Sampaio, Paula Gonçalves

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003587

H-NS Can Facilitate Specific DNA-binding by RNA Polymerase in AT-rich Gene Regulatory Regions

Shivani S. Singh, David C. Grainger

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003589

Functional Analysis of Neuronal MicroRNAs in Caenorhabditis elegans Dauer Formation by Combinational Genetics and Neuronal miRISC Immunoprecipitation

Minh T. Than, Brian A. Kudlow, Min Han

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003592

DeepSAGE Reveals Genetic Variants Associated with Alternative Polyadenylation and Expression of Coding and Non-coding Transcripts

Daria V. Zhernakova, Eleonora de Klerk, Harm-Jan Westra, Anastasios Mastrokolias, Shoaib Amini, Yavuz Ariyurek, Rick Jansen, Brenda W. Penninx, Jouke J. Hottenga, Gonneke Willemsen, Eco J. de Geus, Dorret I. Boomsma, Jan H. Veldink, Leonard H. van den Berg, Cisca Wijmenga, Johan T. den Dunnen, Gert-Jan B. van Ommen, Peter A. C. 't Hoen, Lude Franke

PLOS Genetics: published June 20, 2013 | https://doi.org/10.1371/journal.pgen.1003594

Distinctive Expansion of Potential Virulence Genes in the Genome of the Oomycete Fish Pathogen Saprolegnia parasitica

Rays H. Y. Jiang, Irene de Bruijn, Brian J. Haas, Rodrigo Belmonte, Lars Löbach, James Christie, Guido van den Ackerveken, Arnaud Bottin, Vincent Bulone, Sara M. Díaz-Moreno, Bernard Dumas, Lin Fan, Elodie Gaulin, Francine Govers, Laura J. Grenville-Briggs, Neil R. Horner, Joshua Z. Levin, Marco Mammella, Harold J. G. Meijer, Paul Morris, Chad Nusbaum, Stan Oome, Andrew J. Phillips, David van Rooyen, Elzbieta Rzeszutek, Marcia Saraiva, Chris J. Secombes, Michael F. Seidl, Berend Snel, Joost H. M. Stassen, Sean Sykes, Sucheta Tripathy, Herbert van den Berg, Julio C. Vega-Arreguin, Stephan Wawra, Sarah K. Young, Qiandong Zeng, Javier Dieguez-Uribeondo, Carsten Russ, Brett M. Tyler, Pieter van West

PLOS Genetics: published June 13, 2013 | https://doi.org/10.1371/journal.pgen.1003272

Effectively Identifying eQTLs from Multiple Tissues by Combining Mixed Model and Meta-analytic Approaches

Jae Hoon Sul, Buhm Han, Chun Ye, Ted Choi, Eleazar Eskin

PLOS Genetics: published June 13, 2013 | https://doi.org/10.1371/journal.pgen.1003491

PARP-1 Regulates Metastatic Melanoma through Modulation of Vimentin-induced Malignant Transformation

María Isabel Rodríguez, Andreína Peralta-Leal, Francisco O'Valle, José Manuel Rodriguez-Vargas, Ariannys Gonzalez-Flores, Jara Majuelos-Melguizo, Laura López, Santiago Serrano, Antonio García de Herreros, Juan Carlos Rodríguez-Manzaneque, Rubén Fernández, Raimundo G. del Moral, José Mariano de Almodóvar, F. Javier Oliver

PLOS Genetics: published June 13, 2013 | https://doi.org/10.1371/journal.pgen.1003531

The Gene Desert Mammary Carcinoma Susceptibility Locus Mcs1a Regulates Nr2f1 Modifying Mammary Epithelial Cell Differentiation and Proliferation

Bart M. G. Smits, Jill D. Haag, Anna I. Rissman, Deepak Sharma, Ann Tran, Alexi A. Schoenborn, Rachael C. Baird, Dan S. Peiffer, David Q. Leinweber, Matthew J. Muelbl, Amanda L. Meilahn, Mark R. Eichelberg, Ning Leng, Christina Kendziorski, Manorama C. John, Patricia A. Powers, Caroline M. Alexander, Michael N. Gould

PLOS Genetics: published June 13, 2013 | https://doi.org/10.1371/journal.pgen.1003549

Deregulation of the Protocadherin Gene FAT1 Alters Muscle Shapes: Implications for the Pathogenesis of Facioscapulohumeral Dystrophy

Nathalie Caruso, Balàzs Herberth, Marc Bartoli, Francesca Puppo, Julie Dumonceaux, Angela Zimmermann, Simon Denadai, Marie Lebossé, Stephane Roche, Linda Geng, Frederique Magdinier, Shahram Attarian, Rafaelle Bernard, Flavio Maina, Nicolas Levy, Françoise Helmbacher

PLOS Genetics: published June 13, 2013 | https://doi.org/10.1371/journal.pgen.1003550

Fragile DNA Motifs Trigger Mutagenesis at Distant Chromosomal Loci in Saccharomyces cerevisiae

Natalie Saini, Yu Zhang, Yuri Nishida, Ziwei Sheng, Shilpa Choudhury, Piotr Mieczkowski, Kirill S. Lobachev

PLOS Genetics: published June 13, 2013 | https://doi.org/10.1371/journal.pgen.1003551

NSAIDs Modulate Clonal Evolution in Barrett's Esophagus

Rumen L. Kostadinov, Mary K. Kuhner, Xiaohong Li, Carissa A. Sanchez, Patricia C. Galipeau, Thomas G. Paulson, Cassandra L. Sather, Amitabh Srivastava, Robert D. Odze, Patricia L. Blount, Thomas L. Vaughan, Brian J. Reid, Carlo C. Maley

PLOS Genetics: published June 13, 2013 | https://doi.org/10.1371/journal.pgen.1003553

Meiosis-Specific Stable Binding of Augmin to Acentrosomal Spindle Poles Promotes Biased Microtubule Assembly in Oocytes

Nathalie Colombié, A. Agata Głuszek, Ana M. Meireles, Hiroyuki Ohkura

PLOS Genetics: published June 13, 2013 | https://doi.org/10.1371/journal.pgen.1003562

Multi-organ Abnormalities and mTORC1 Activation in Zebrafish Model of Multiple Acyl-CoA Dehydrogenase Deficiency

Seok-Hyung Kim, Sarah A. Scott, Michael J. Bennett, Robert P. Carson, Joshua Fessel, H. Alex Brown, Kevin C. Ess

PLOS Genetics: published June 13, 2013 | https://doi.org/10.1371/journal.pgen.1003563

High Trans-ethnic Replicability of GWAS Results Implies Common Causal Variants

Urko M. Marigorta, Arcadi Navarro

PLOS Genetics: published June 13, 2013 | https://doi.org/10.1371/journal.pgen.1003566

Breakage-fusion-bridge Cycles and Large Insertions Contribute to the Rapid Evolution of Accessory Chromosomes in a Fungal Pathogen

Daniel Croll, Marcello Zala, Bruce A. McDonald

PLOS Genetics: published June 13, 2013 | https://doi.org/10.1371/journal.pgen.1003567

Causes and Consequences of Chromatin Variation between Inbred Mice

Mona Hosseini, Leo Goodstadt, Jim R. Hughes, Monika S. Kowalczyk, Marco de Gobbi, Georg W. Otto, Richard R. Copley, Richard Mott, Douglas R. Higgs, Jonathan Flint

PLOS Genetics: published June 13, 2013 | https://doi.org/10.1371/journal.pgen.1003570

BMS1 Is Mutated in Aplasia Cutis Congenita

Alexander G. Marneros

PLOS Genetics: published June 13, 2013 | https://doi.org/10.1371/journal.pgen.1003573

Altered Splicing of the BIN1 Muscle-Specific Exon in Humans and Dogs with Highly Progressive Centronuclear Myopathy

Johann Böhm, Nasim Vasli, Marie Maurer, Belinda Cowling, G. Diane Shelton, Wolfram Kress, Anne Toussaint, Ivana Prokic, Ulrike Schara, Thomas James Anderson, Joachim Weis, Laurent Tiret, Jocelyn Laporte

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003430

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Joshua C. Randall, Thomas W. Winkler, Zoltán Kutalik, Sonja I. Berndt, Anne U. Jackson, Keri L. Monda, Tuomas O. Kilpeläinen, Tõnu Esko, Reedik Mägi, Shengxu Li, Tsegaselassie Workalemahu, Mary F. Feitosa, Damien C. Croteau-Chonka, Felix R. Day, Tove Fall, Teresa Ferreira, Stefan Gustafsson, Adam E. Locke, Iain Mathieson, Andre Scherag, Sailaja Vedantam, Andrew R. Wood, Liming Liang, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Emmanouil T. Dermitzakis, Antigone S. Dimas, Fredrik Karpe, Josine L. Min, George Nicholson, Deborah J. Clegg, Thomas Person, Jon P. Krohn, Sabrina Bauer, Christa Buechler, Kristina Eisinger, DIAGRAM Consortium, Amélie Bonnefond, Philippe Froguel, MAGIC Investigators, Jouke-Jan Hottenga, Inga Prokopenko, Lindsay L. Waite, Tamara B. Harris, Albert Vernon Smith, Alan R. Shuldiner, Wendy L. McArdle, Mark J. Caulfield, Patricia B. Munroe, Henrik Grönberg, Yii-Der Ida Chen, Guo Li, Jacques S. Beckmann, Toby Johnson, Unnur Thorsteinsdottir, Maris Teder-Laving, Kay-Tee Khaw, Nicholas J. Wareham, Jing Hua Zhao, Najaf Amin, Ben A. Oostra, Aldi T. Kraja, Michael A. Province, L. Adrienne Cupples, Nancy L. Heard-Costa, Jaakko Kaprio, Samuli Ripatti, Ida Surakka, Francis S. Collins, Jouko Saramies, Jaakko Tuomilehto, Antti Jula, Veikko Salomaa, Jeanette Erdmann, Christian Hengstenberg, Christina Loley, Heribert Schunkert, Claudia Lamina, H. Erich Wichmann, Eva Albrecht, Christian Gieger, Andrew A. Hicks, Åsa Johansson, Peter P. Pramstaller, Sekar Kathiresan, Elizabeth K. Speliotes, Brenda Penninx, Anna-Liisa Hartikainen, Marjo-Riitta Jarvelin, Ulf Gyllensten, Dorret I. Boomsma, Harry Campbell, James F. Wilson, Stephen J. Chanock, Martin Farrall, Anuj Goel, Carolina Medina-Gomez, Fernando Rivadeneira, Karol Estrada, André G. Uitterlinden, Albert Hofman, M. Carola Zillikens, Martin den Heijer, Lambertus A. Kiemeney, Andrea Maschio, Per Hall, Jonathan Tyrer, Alexander Teumer, Henry Völzke, Peter Kovacs, Anke Tönjes, Massimo Mangino, Tim D. Spector, Caroline Hayward, Igor Rudan, Alistair S. Hall, Nilesh J. Samani, Antony Paul Attwood, Jennifer G. Sambrook, Joseph Hung, Lyle J. Palmer, Marja-Liisa Lokki, Juha Sinisalo, Gabrielle Boucher, Heikki Huikuri, Mattias Lorentzon, Claes Ohlsson, Niina Eklund, Johan G. Eriksson, Cristina Barlassina, Carlo Rivolta, Ilja M. Nolte, Harold Snieder, Melanie M. Van der Klauw, Jana V. Van Vliet-Ostaptchouk, Pablo V. Gejman, Jianxin Shi, Kevin B. Jacobs, Zhaoming Wang, Stephan J. L. Bakker, Irene Mateo Leach, Gerjan Navis, Pim van der Harst, Nicholas G. Martin, Sarah E. Medland, Grant W. Montgomery, Jian Yang, Daniel I. Chasman, Paul M. Ridker, Lynda M. Rose, Terho Lehtimäki, Olli Raitakari, Devin Absher, Carlos Iribarren, Hanneke Basart, Kees G. Hovingh, Elina Hyppönen, Chris Power, Denise Anderson, John P. Beilby, Jennie Hui, Jennifer Jolley, Hendrik Sager, Stefan R. Bornstein, Peter E. H. Schwarz, Kati Kristiansson, Markus Perola, Jaana Lindström, Amy J. Swift, Matti Uusitupa, Mustafa Atalay, Timo A. Lakka, Rainer Rauramaa, Jennifer L. Bolton, Gerry Fowkes, Ross M. Fraser, Jackie F. Price, Krista Fischer, Kaarel KrjutÅ¡kov, Andres Metspalu, Evelin Mihailov, Claudia Langenberg, Jian'an Luan, Ken K. Ong, Peter S. Chines, Sirkka M. Keinanen-Kiukaanniemi, Timo E. Saaristo, Sarah Edkins, Paul W. Franks, Göran Hallmans, Dmitry Shungin, Andrew David Morris, Colin N. A. Palmer, Raimund Erbel, Susanne Moebus, Markus M. Nöthen, Sonali Pechlivanis, Kristian Hveem, Narisu Narisu, Anders Hamsten, Steve E. Humphries, Rona J. Strawbridge, Elena Tremoli, Harald Grallert, Barbara Thorand, Thomas Illig, Wolfgang Koenig, Martina Müller-Nurasyid, Annette Peters, Bernhard O. Boehm, Marcus E. Kleber, Winfried März, Bernhard R. Winkelmann, Johanna Kuusisto, Markku Laakso, Dominique Arveiler, Giancarlo Cesana, Kari Kuulasmaa, Jarmo Virtamo, John W. G. Yarnell, Diana Kuh, Andrew Wong, Lars Lind, Ulf de Faire, Bruna Gigante, Patrik K. E. Magnusson, Nancy L. Pedersen, George Dedoussis, Maria Dimitriou, Genovefa Kolovou, Stavroula Kanoni, Kathleen Stirrups, Lori L. Bonnycastle, Inger Njølstad, Tom Wilsgaard, Andrea Ganna, Emil Rehnberg, Aroon Hingorani, Mika Kivimaki, Meena Kumari, Themistocles L. Assimes, Inês Barroso, Michael Boehnke, Ingrid B. Borecki, Panos Deloukas, Caroline S. Fox, Timothy Frayling, Leif C. Groop, Talin Haritunians, David Hunter, Erik Ingelsson, Robert Kaplan, Karen L. Mohlke, Jeffrey R. O'Connell, David Schlessinger, David P. Strachan, Kari Stefansson, Cornelia M. van Duijn, Gonçalo R. Abecasis, Mark I. McCarthy, Joel N. Hirschhorn, Lu Qi, Ruth J. F. Loos, Cecilia M. Lindgren, Kari E. North, Iris M. Heid

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003500

Impact of Natural Genetic Variation on Gene Expression Dynamics

Marit Ackermann, Weronika Sikora-Wohlfeld, Andreas Beyer

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003514

Global DNA Hypermethylation in Down Syndrome Placenta

Shengnan Jin, Yew Kok Lee, Yen Ching Lim, Zejun Zheng, Xueqin Michelle Lin, Desmond P. Y. Ng, Joanna D. Holbrook, Hai Yang Law, Kenneth Y. C. Kwek, George S. H. Yeo, Chunming Ding

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003515

Histone Acetyl Transferase 1 Is Essential for Mammalian Development, Genome Stability, and the Processing of Newly Synthesized Histones H3 and H4

Prabakaran Nagarajan, Zhongqi Ge, Bianca Sirbu, Cheryl Doughty, Paula A. Agudelo Garcia, Michaela Schlederer, Anthony T. Annunziato, David Cortez, Lukas Kenner, Mark R. Parthun

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003518

Inferring Demographic History from a Spectrum of Shared Haplotype Lengths

Kelley Harris, Rasmus Nielsen

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003521

Network Topologies and Convergent Aetiologies Arising from Deletions and Duplications Observed in Individuals with Autism

Hyun Ji Noh, Chris P. Ponting, Hannah C. Boulding, Stephen Meader, Catalina Betancur, Joseph D. Buxbaum, Dalila Pinto, Christian R. Marshall, Anath C. Lionel, Stephen W. Scherer, Caleb Webber

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003523

USF1 and hSET1A Mediated Epigenetic Modifications Regulate Lineage Differentiation and HoxB4 Transcription

Changwang Deng, Ying Li, Shermi Liang, Kairong Cui, Tal Salz, Hui Yang, Zhanyun Tang, Patrick G. Gallagher, Yi Qiu, Robert Roeder, Keji Zhao, Jörg Bungert, Suming Huang

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003524

The RNA Export Factor, Nxt1, Is Required for Tissue Specific Transcriptional Regulation

Simona Caporilli, Yachuan Yu, Jianqiao Jiang, Helen White-Cooper

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003526

Genetic Architecture of Vitamin B₁₂ and Folate Levels Uncovered Applying Deeply Sequenced Large Datasets

Niels Grarup, Patrick Sulem, Camilla H. Sandholt, Gudmar Thorleifsson, Tarunveer S. Ahluwalia, Valgerdur Steinthorsdottir, Helgi Bjarnason, Daniel F. Gudbjartsson, Olafur T. Magnusson, Thomas Sparsø, Anders Albrechtsen, Augustine Kong, Gisli Masson, Geng Tian, Hongzhi Cao, Chao Nie, Karsten Kristiansen, Lise Lotte Husemoen, Betina Thuesen, Yingrui Li, Rasmus Nielsen, Allan Linneberg, Isleifur Olafsson, Gudmundur I. Eyjolfsson, Torben Jørgensen, Jun Wang, Torben Hansen, Unnur Thorsteinsdottir, Kari Stefánsson, Oluf Pedersen

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003530

Distinct Neuroblastoma-associated Alterations of PHOX2B Impair Sympathetic Neuronal Differentiation in Zebrafish Models

Desheng Pei, William Luther, Wenchao Wang, Barry H. Paw, Rodney A. Stewart, Rani E. George

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003533

A Genome-Wide, Fine-Scale Map of Natural Pigmentation Variation in Drosophila melanogaster

Héloïse Bastide, Andrea Betancourt, Viola Nolte, Raymond Tobler, Petra Stöbe, Andreas Futschik, Christian Schlötterer

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003534

Juvenile Hormone and Insulin Regulate Trehalose Homeostasis in the Red Flour Beetle, Tribolium castaneum

Jingjing Xu, Zhentao Sheng, Subba Reddy Palli

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003535

Mutations in CERS3 Cause Autosomal Recessive Congenital Ichthyosis in Humans

Franz P. W. Radner, Slaheddine Marrakchi, Peter Kirchmeier, Gwang-Jin Kim, Florence Ribierre, Bourane Kamoun, Leila Abid, Michael Leipoldt, Hamida Turki, Werner Schempp, Roland Heilig, Mark Lathrop, Judith Fischer

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003536

SPO11-Independent DNA Repair Foci and Their Role in Meiotic Silencing

Fabrizia Carofiglio, Akiko Inagaki, Sandra de Vries, Evelyne Wassenaar, Sam Schoenmakers, Christie Vermeulen, Wiggert A. van Cappellen, Esther Sleddens-Linkels, J. Anton Grootegoed, Hein P. J. te Riele, Bernard de Massy, Willy M. Baarends

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003538

Enterococcus faecalis Prophage Dynamics and Contributions to Pathogenic Traits

Renata C. Matos, Nicolas Lapaque, Lionel Rigottier-Gois, Laurent Debarbieux, Thierry Meylheuc, Bruno Gonzalez-Zorn, Francis Repoila, Maria de Fatima Lopes, Pascale Serror

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003539

Methylation of Histone H3 on Lysine 79 Associates with a Group of Replication Origins and Helps Limit DNA Replication Once per Cell Cycle

Haiqing Fu, Alika K. Maunakea, Melvenia M. Martin, Liang Huang, Ya Zhang, Michael Ryan, RyangGuk Kim, Chii Meil Lin, Keji Zhao, Mirit I. Aladjem

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003542

RSR-2, the Caenorhabditis elegans Ortholog of Human Spliceosomal Component SRm300/SRRM2, Regulates Development by Influencing the Transcriptional Machinery

Laura Fontrodona, Montserrat Porta-de-la-Riva, Tomás Morán, Wei Niu, Mònica Díaz, David Aristizábal-Corrales, Alberto Villanueva, Simó Schwartz Jr, Valerie Reinke, Julián Cerón

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003543

Negative Regulation of Notch Signaling by Xylose

Tom V. Lee, Maya K. Sethi, Jessica Leonardi, Nadia A. Rana, Falk F. R. Buettner, Robert S. Haltiwanger, Hans Bakker, Hamed Jafar-Nejad

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003547

Comparative Polygenic Analysis of Maximal Ethanol Accumulation Capacity and Tolerance to High Ethanol Levels of Cell Proliferation in Yeast

Thiago M. Pais, María R. Foulquié-Moreno, Georg Hubmann, Jorge Duitama, Steve Swinnen, Annelies Goovaerts, Yudi Yang, Françoise Dumortier, Johan M. Thevelein

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003548

H3.3-H4 Tetramer Splitting Events Feature Cell-Type Specific Enhancers

Chang Huang, Zhuqiang Zhang, Mo Xu, Yingfeng Li, Zhen Li, Yanting Ma, Tao Cai, Bing Zhu

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003558

Negative Regulation of the Novel norpA^P24 Suppressor, diehard4, in the Endo-lysosomal Trafficking Underlies Photoreceptor Cell Degeneration

Jongwoo Lee, Myungchul Song, Sujeong Hong

PLOS Genetics: published June 6, 2013 | https://doi.org/10.1371/journal.pgen.1003559

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Drosophila testis and male genital tract showing expression of a reporter construct

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