Expression of mutant Shp2 with a mutation that was identified in human Noonan Syndrome results in a range of defects in zebrafish embryos, including shortening of the body axis (top three embryos) compared to a control non-injected embryo (bottom) (see Jopling et al., e225).
Image Credit: Photograph provided by Chris Jopling, Hubrecht Institute.
Editorial
Entropy Explains Aging, Genetic Determinism Explains Longevity, and Undefined Terminology Explains Misunderstanding Both
PLOS Genetics: published December 14, 2007 | https://doi.org/10.1371/journal.pgen.0030220
Perspective
A Bacterial Kind of Aging
PLOS Genetics: published December 14, 2007 | https://doi.org/10.1371/journal.pgen.0030224
Research Articles
The Role of Carcinine in Signaling at the Drosophila Photoreceptor Synapse
PLOS Genetics: published December 7, 2007 | https://doi.org/10.1371/journal.pgen.0030206
Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability
PLOS Genetics: published December 14, 2007 | https://doi.org/10.1371/journal.pgen.0030215
Localization of Candidate Regions Maintaining a Common Polymorphic Inversion (2La) in Anopheles gambiae
PLOS Genetics: published December 7, 2007 | https://doi.org/10.1371/journal.pgen.0030217
A RNA Interference Screen Identifies the Protein Phosphatase 2A Subunit PR55γ as a Stress-Sensitive Inhibitor of c-SRC
PLOS Genetics: published December 7, 2007 | https://doi.org/10.1371/journal.pgen.0030218
A Mechanism Misregulating p27 in Tumors Discovered in a Functional Genomic Screen
PLOS Genetics: published December 7, 2007 | https://doi.org/10.1371/journal.pgen.0030219
Novel Roles for Selected Genes in Meiotic DNA Processing
PLOS Genetics: published December 7, 2007 | https://doi.org/10.1371/journal.pgen.0030222
Shp2 Knockdown and Noonan/LEOPARD Mutant Shp2–Induced Gastrulation Defects
PLOS Genetics: published December 21, 2007 | https://doi.org/10.1371/journal.pgen.0030225
Chromosome Structuring Limits Genome Plasticity in Escherichia coli
PLOS Genetics: published December 14, 2007 | https://doi.org/10.1371/journal.pgen.0030226
Argonaute2 Is Essential for Mammalian Gastrulation and Proper Mesoderm Formation
PLOS Genetics: published December 28, 2007 | https://doi.org/10.1371/journal.pgen.0030227
Genome-Wide Analysis of Rad52 Foci Reveals Diverse Mechanisms Impacting Recombination
PLOS Genetics: published December 14, 2007 | https://doi.org/10.1371/journal.pgen.0030228
Experimental Characterization of Cis-Acting Elements Important for Translation and Transcription in Halophilic Archaea
PLOS Genetics: published December 21, 2007 | https://doi.org/10.1371/journal.pgen.0030229
Patterns and Implications of Gene Gain and Loss in the Evolution of Prochlorococcus
PLOS Genetics: published December 21, 2007 | https://doi.org/10.1371/journal.pgen.0030231
Distinct Roles and Regulations for Hoxd Genes in Metanephric Kidney Development
PLOS Genetics: published December 21, 2007 | https://doi.org/10.1371/journal.pgen.0030232
Conserved Regulation of MAP Kinase Expression by PUF RNA-Binding Proteins
PLOS Genetics: published December 28, 2007 | https://doi.org/10.1371/journal.pgen.0030233
dAtaxin-2 Mediates Expanded Ataxin-1-Induced Neurodegeneration in a Drosophila Model of SCA1
PLOS Genetics: published December 28, 2007 | https://doi.org/10.1371/journal.pgen.0030234
Deletion of the MBII-85 snoRNA Gene Cluster in Mice Results in Postnatal Growth Retardation
PLOS Genetics: published December 28, 2007 | https://doi.org/10.1371/journal.pgen.0030235
Human Subtelomeric WASH Genes Encode a New Subclass of the WASP Family
PLOS Genetics: published December 21, 2007 | https://doi.org/10.1371/journal.pgen.0030237
Sustained Post-Mating Response in Drosophila melanogaster Requires Multiple Seminal Fluid Proteins
PLOS Genetics: published December 14, 2007 | https://doi.org/10.1371/journal.pgen.0030238
Correspondence
A Tribute to Marcy Carlson Speer, 1959–2007
PLOS Genetics: published December 28, 2007 | https://doi.org/10.1371/journal.pgen.0030230