Figures
Necrotic protein uptake in garland cells.
The garland cells are one of two groups of athrocytes in Drosophila in which extracellular serpin-family inhibitors involved in the innate immune response are taken up and degraded (see Soukup et al., 10.1371/journal.pgen.1000532). The image shows a broken ring of garland cells encircling the oesophagus above the proventriculus (Z-series reconstruction). Endocytosis has been frozen using a Dynamints mutation, allowing Necrotic (red) to be detected within the cortical labyrinthine channels of the garland cells. In a normal fly, Necrotic is endocytosed via the LpR1 trafficking receptor, processed through multi-vesicular bodies, and delivered to the lysosome for degradation.
Image Credit: Picture taken by Dr. Sandra Soukup in the laboratory of Dr. David Gubb (CICbioGUNE Institute, Derio, Spain).
Citation: (2009) PLoS Genetics Issue Image | Vol. 5(6) June 2009. PLoS Genet 5(6): ev05.i06. https://doi.org/10.1371/image.pgen.v05.i06
Published: June 26, 2009
Copyright: © 2009 Soukup et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The garland cells are one of two groups of athrocytes in Drosophila in which extracellular serpin-family inhibitors involved in the innate immune response are taken up and degraded (see Soukup et al., 10.1371/journal.pgen.1000532). The image shows a broken ring of garland cells encircling the oesophagus above the proventriculus (Z-series reconstruction). Endocytosis has been frozen using a Dynamints mutation, allowing Necrotic (red) to be detected within the cortical labyrinthine channels of the garland cells. In a normal fly, Necrotic is endocytosed via the LpR1 trafficking receptor, processed through multi-vesicular bodies, and delivered to the lysosome for degradation.
Image Credit: Picture taken by Dr. Sandra Soukup in the laboratory of Dr. David Gubb (CICbioGUNE Institute, Derio, Spain).