Figures
Using yeast to understand the side effects of psychoactive drugs.
Neuropsychiatric disorders such as depression and psychosis affect 1/4 of all individuals during their lifetime, and despite efforts to improve the selectivity of psychoactive drugs, all are associated with side effects. Using a genome-wide chemogenomic assay, the authors found that these medications perturbed many evolutionarily conserved genes and cellular pathways (see Ericson et al., doi:10.1371/journal.pgen.1000151).
Image Credit: Trine Giaever
Citation: (2008) PLoS Genetics Issue Image | Vol. 4(8) August 2008. PLoS Genet 4(8): ev04.i08. https://doi.org/10.1371/image.pgen.v04.i08
Published: August 29, 2008
Copyright: © 2008 Ericson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Neuropsychiatric disorders such as depression and psychosis affect 1/4 of all individuals during their lifetime, and despite efforts to improve the selectivity of psychoactive drugs, all are associated with side effects. Using a genome-wide chemogenomic assay, the authors found that these medications perturbed many evolutionarily conserved genes and cellular pathways (see Ericson et al., doi:10.1371/journal.pgen.1000151).
Image Credit: Trine Giaever