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Open Access
Peer-reviewed
Research Article
Integrated Model of De Novo and Inherited Genetic Variants Yields Greater Power to Identify Risk Genes
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Xin He,
Affiliation Lane Center of Computational Biology, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
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Stephan J. Sanders,
Affiliation Departments of Psychiatry and Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America
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Li Liu,
Affiliation Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
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Silvia De Rubeis,
Affiliations Seaver Autism Center for Research and Treatment, Icahn Mount Sinai School of Medicine, New York, New York, United States of America, Department of Psychiatry, Icahn Mount Sinai School of Medicine, New York, New York, United States of America
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Elaine T. Lim,
Affiliations Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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James S. Sutcliffe,
Affiliation Vanderbilt Brain Institute, Departments of Molecular Physiology & Biophysics and Psychiatry, Vanderbilt University, Nashville, Tennessee, United States of America
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Gerard D. Schellenberg,
Affiliation Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Richard A. Gibbs,
Affiliation Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America
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Mark J. Daly,
Affiliations Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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Joseph D. Buxbaum,
Affiliations Seaver Autism Center for Research and Treatment, Icahn Mount Sinai School of Medicine, New York, New York, United States of America, Department of Psychiatry, Icahn Mount Sinai School of Medicine, New York, New York, United States of America, Department of Genetics and Genomic Sciences, Icahn Mount Sinai School of Medicine, New York, New York, United States of America, Friedman Brain Institute, Icahn Mount Sinai School of Medicine, New York, New York, United States of America
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Matthew W. State,
Affiliation Departments of Psychiatry and Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America
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Bernie Devlin,
Affiliation Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Kathryn Roeder
* E-mail: roeder@stat.cmu.edu
Affiliations Lane Center of Computational Biology, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America, Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
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Integrated Model of De Novo and Inherited Genetic Variants Yields Greater Power to Identify Risk Genes
- Xin He,
- Stephan J. Sanders,
- Li Liu,
- Silvia De Rubeis,
- Elaine T. Lim,
- James S. Sutcliffe,
- Gerard D. Schellenberg,
- Richard A. Gibbs,
- Mark J. Daly,
- Joseph D. Buxbaum
- Published: August 15, 2013
- https://doi.org/10.1371/journal.pgen.1003671