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Open Access
Peer-reviewed
Research Article
Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
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Elizabeth K. Speliotes ,
Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki
* E-mail: espeliot@med.umich.edu (EKS); iborecki@wustl.edu (IBB)
Affiliations Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America
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Laura M. Yerges-Armstrong ,
Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki
Affiliation Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
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Jun Wu ,
Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki
Affiliation Division of Statistical Genomics, Department of Genetics, Washington University, Saint Louis, Missouri, United States of America
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Ruben Hernaez ,
Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki
Affiliations Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Division of General Internal Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, United States of America, Department of Internal Medicine, Washington Hospital Center, Washington D.C., United States of America
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Lauren J. Kim ,
Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki
Affiliation Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
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Cameron D. Palmer,
Affiliation Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America
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Vilmundur Gudnason,
Affiliations Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland
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Gudny Eiriksdottir,
Affiliation Icelandic Heart Association, Kopavogur, Iceland
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Melissa E. Garcia,
Affiliation Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
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Lenore J. Launer,
Affiliation Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
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Michael A. Nalls,
Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
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Jeanne M. Clark,
Affiliations Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Division of General Internal Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, United States of America
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Braxton D. Mitchell,
Affiliation Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
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Alan R. Shuldiner,
Affiliations Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Geriatric Research and Education Clinical Center (GRECC), Veterans Administration Medical Center, Baltimore, Maryland, United States of America
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Johannah L. Butler,
Affiliations Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America, Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America
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Marta Tomas,
Affiliations Cardiovascular Epidemiology and Genetics, Institut Municipal d'Investigació Mèdica, Barcelona, Spain, CIBER Epidemiología y Salud Pública, Barcelona, Spain
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Udo Hoffmann,
Affiliations Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
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Shih-Jen Hwang,
Affiliation Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, Massachusetts, United States of America
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Joseph M. Massaro,
Affiliations Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
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Christopher J. O'Donnell,
Affiliations Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, Massachusetts, United States of America, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America
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Dushyant V. Sahani,
Affiliation Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
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Veikko Salomaa,
Affiliation Chronic Disease Epidemiology Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
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Eric E. Schadt,
Affiliation Pacific Biosciences, Menlo Park, California, United States of America
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Stephen M. Schwartz,
Affiliations Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
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David S. Siscovick,
Affiliation Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America
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NASH CRN ,
¶For membership information, please see Acknowledgments.
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GIANT Consortium ,
¶For membership information, please see Acknowledgments.
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MAGIC Investigators ,
¶For membership information, please see Acknowledgments.
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Benjamin F. Voight,
Affiliation Broad Institute, Cambridge, Massachusetts, United States of America
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J. Jeffrey Carr,
Affiliation Departments of Radiologic Sciences, Internal Medicine-Cardiology, and Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
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Mary F. Feitosa,
Affiliation Division of Statistical Genomics, Department of Genetics, Washington University, Saint Louis, Missouri, United States of America
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Tamara B. Harris,
Affiliation Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
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Caroline S. Fox,
Affiliations Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, Massachusetts, United States of America, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America
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Albert V. Smith ,
Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki
Affiliation Icelandic Heart Association, Kopavogur, Iceland
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W. H. Linda Kao ,
Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki
Affiliations Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, United States of America
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Joel N. Hirschhorn ,
Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki
Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
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Ingrid B. Borecki ,
Contributed equally to this work with: Elizabeth K. Speliotes, Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Albert V. Smith, W. H. Linda Kao, Joel N. Hirschhorn, Ingrid B. Borecki
* E-mail: espeliot@med.umich.edu (EKS); iborecki@wustl.edu (IBB)
Affiliation Division of Statistical Genomics, Department of Genetics, Washington University, Saint Louis, Missouri, United States of America
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GOLD Consortium
¶For membership information, please see Acknowledgments.
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Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
- Elizabeth K. Speliotes,
- Laura M. Yerges-Armstrong,
- Jun Wu,
- Ruben Hernaez,
- Lauren J. Kim,
- Cameron D. Palmer,
- Vilmundur Gudnason,
- Gudny Eiriksdottir,
- Melissa E. Garcia,
- Lenore J. Launer
- Published: March 10, 2011
- https://doi.org/10.1371/journal.pgen.1001324