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Genomics Meets Glycomics—The First GWAS Study of Human N-Glycome Identifies HNF1α as a Master Regulator of Plasma Protein Fucosylation

  • Gordan Lauc ,

    Contributed equally to this work with: Gordan Lauc, Abdelkader Essafi, Jennifer E. Huffman, Caroline Hayward

    Affiliations Glycobiology Laboratory, Genos Ltd., Zagreb, Croatia, Department of Biochemistry and Molecular Biology, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia

  • Abdelkader Essafi ,

    Contributed equally to this work with: Gordan Lauc, Abdelkader Essafi, Jennifer E. Huffman, Caroline Hayward

    Affiliation Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

  • Jennifer E. Huffman ,

    Contributed equally to this work with: Gordan Lauc, Abdelkader Essafi, Jennifer E. Huffman, Caroline Hayward

    Affiliation Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

  • Caroline Hayward ,

    Contributed equally to this work with: Gordan Lauc, Abdelkader Essafi, Jennifer E. Huffman, Caroline Hayward

    Affiliation Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

  • Ana Knežević,

    Affiliation Department of Biochemistry and Molecular Biology, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia

  • Jayesh J. Kattla,

    Affiliations National Institute for Bioprocessing Research and Training, Dublin-Oxford Glycobiology Lab, Conway Institute, University College Dublin, Dublin, Ireland, Conway Institute, University College Dublin, Dublin, Ireland

  • Ozren Polašek,

    Affiliations Gen Info Ltd., Zagreb, Croatia, Medical School, University of Zagreb, Zagreb, Croatia

  • Olga Gornik,

    Affiliation Department of Biochemistry and Molecular Biology, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia

  • Veronique Vitart,

    Affiliation Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

  • Jodie L. Abrahams,

    Affiliations National Institute for Bioprocessing Research and Training, Dublin-Oxford Glycobiology Lab, Conway Institute, University College Dublin, Dublin, Ireland, Conway Institute, University College Dublin, Dublin, Ireland

  • Maja Pučić,

    Affiliation Glycobiology Laboratory, Genos Ltd., Zagreb, Croatia

  • Mislav Novokmet,

    Affiliation Glycobiology Laboratory, Genos Ltd., Zagreb, Croatia

  • Irma Redžić,

    Affiliation Department of Biochemistry and Molecular Biology, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia

  • Susan Campbell,

    Affiliation Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

  • Sarah H. Wild,

    Affiliation Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, United Kingdom

  • Fran Borovečki,

    Affiliation Medical School, University of Zagreb, Zagreb, Croatia

  • Wei Wang,

    Affiliations School of Public Health and Family Medicine, Capital Medical University, Beijing, China, Graduate School of the Chinese Academy of Sciences, Beijing, China, Croatian Centre for Global Health, University of Split Medical School, Split, Croatia

  • Ivana Kolčić,

    Affiliation Medical School, University of Zagreb, Zagreb, Croatia

  • Lina Zgaga,

    Affiliation Medical School, University of Zagreb, Zagreb, Croatia

  • Ulf Gyllensten,

    Affiliation Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

  • James F. Wilson ,

    These authors also contributed equally to this work.

    Affiliation Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, United Kingdom

  • Alan F. Wright ,

    These authors also contributed equally to this work.

    Affiliation Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

  • Nicholas D. Hastie ,

    These authors also contributed equally to this work.

    Affiliation Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

  • Harry Campbell ,

    These authors also contributed equally to this work.

    Affiliation Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, United Kingdom

  • Pauline M. Rudd ,

    These authors also contributed equally to this work.

    Affiliations National Institute for Bioprocessing Research and Training, Dublin-Oxford Glycobiology Lab, Conway Institute, University College Dublin, Dublin, Ireland, Conway Institute, University College Dublin, Dublin, Ireland

  •  [ ... ],
  • Igor Rudan

    irudan@hotmail.com

    These authors also contributed equally to this work.

    Affiliations Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, United Kingdom, Croatian Centre for Global Health, University of Split Medical School, Split, Croatia

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Genomics Meets Glycomics—The First GWAS Study of Human N-Glycome Identifies HNF1α as a Master Regulator of Plasma Protein Fucosylation

  • Gordan Lauc, 
  • Abdelkader Essafi, 
  • Jennifer E. Huffman, 
  • Caroline Hayward, 
  • Ana Knežević, 
  • Jayesh J. Kattla, 
  • Ozren Polašek, 
  • Olga Gornik, 
  • Veronique Vitart, 
  • Jodie L. Abrahams
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