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Beyond the MHC: A canine model of dermatomyositis shows a complex pattern of genetic risk involving novel loci

Fig 4

Frequencies of DMS-associated polymorphisms across breeds.

The number of alleles used to calculate the frequencies is shown to the left of the breed name, if > 10. Risk allele frequencies (x-axis) for each gene are represented by a single, segmented colored bar: the PAN2 variant encoding p.Arg492Cys is represented in purple, MAP3K7CL c.383_392ACTCCACAAA>GACT in gray, and DLA-DRB1*002:01 in orange. The number of homozygous dogs observed is reported on the corresponding color bar. Asterisks denote breeds lacking DLA-DRB1*002:01 in this study, but which were previously reported to possess the allele [57].

Fig 4

doi: https://doi.org/10.1371/journal.pgen.1006604.g004