Differential paralog divergence modulates genome evolution across yeast species
A) Schematic describing the strains that were competed against one another in the chemostat. B) The relative fitness of four strains of S. cerevisiae containing CEN plasmids with a SUL1 or SUL2 allele from S. cerevisiae or S. uvarum was determined in a pairwise manner. The fitness was measured in the chemostat under sulfate-limited conditions against a GFP-marked lab strain also containing CEN plasmids with either SUL1 or SUL2 from S. cerevisiae or S. uvarum. Each bar corresponds to the mean of 4 or more replicates ±SD. The direction of the bar illustrates the strain that is more fit and depends on the strain that is GFP+. The labels on the x-axis describe the dark strain over the GFP+ strain competed against each other, with the most fit strain bolded in black. The fitness ranking of all the alleles is indicated at the bottom.