Advertisement

< Back to Article

Differential paralog divergence modulates genome evolution across yeast species

Fig 2

Alternate paralogs in S. cerevisiae and S. uvarum can amplify but such amplifications are not observed when preferred paralogs are expressed.

A) Schematic illustrating how evolved strains were derived in S. cerevisiae and analyzed by aCGH to generate copy number plots shown below. B) Schematic illustrating how evolved strains were derived in S. uvarum and analyzed by aCGH to generate copy number plots shown below. C) Array CGH of evolved clone versus the parental genome of a sul1Δ S. cerevisiae strain at the relevant genomic segments surrounding the SUL1 (top) and SUL2 (bottom) loci. Array data (gray dots) indicate a copy number amplification. Segmentation-derived regions of average copy number are indicated in red. Segmentation defines a ~144kb region of chromosome VII with a copy number estimation of 3. Genes along the top are represented in the locus in the expanded panel. D) Array CGH of evolved clone versus the parental genomes of a sul2Δ S. uvarum strain at the relevant genomic segments surrounding the SUL1 (top) and SUL2 (bottom) loci. Array data (gray dots) indicate a copy number amplification. Segmentation-derived regions of average copy number are indicated in red. Segmentation defines a ~134kb region of chromosome IV with a copy number estimation of 2. Genes along the top are represented in the locus in the expanded panel.

Fig 2

doi: https://doi.org/10.1371/journal.pgen.1006585.g002