Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7
F40F4.6 RNAi significantly shortened the lifespan of glp-1 germlineless animals, but did not shorten the long lifespan of insulin/IGF1 signaling mutants (daf-2), dietary restricted mutants (eat-2), mutants in mitochondrial respiration mutants (clk-1) or wild-type animals. Mean lifespans and Mantel-Cox P values are indicated within each graph. Mantel Cox P-values for control RNAi vs. irg-7 RNAi-treated wild-type animals are in gray. Mantel Cox P-values for control RNAi vs. irg-7 RNAi-treated long-lived mutants are in blue. See S5 Table for more lifespan data.