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Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7

Fig 5

irg-7 is part of the germline longevity pathway.

F40F4.6 RNAi significantly shortened the lifespan of glp-1 germlineless animals, but did not shorten the long lifespan of insulin/IGF1 signaling mutants (daf-2), dietary restricted mutants (eat-2), mutants in mitochondrial respiration mutants (clk-1) or wild-type animals. Mean lifespans and Mantel-Cox P values are indicated within each graph. Mantel Cox P-values for control RNAi vs. irg-7 RNAi-treated wild-type animals are in gray. Mantel Cox P-values for control RNAi vs. irg-7 RNAi-treated long-lived mutants are in blue. See S5 Table for more lifespan data.

Fig 5

doi: https://doi.org/10.1371/journal.pgen.1006577.g005