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Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7

Fig 3

irg-7(zc6) mutation extends lifespan by increasing pathogen resistance.

(A) Feeding animals with dead OP50 bacteria extended the lifespan of wild-type animals (Mantel-Cox, P<0.001), but did not extend the lifespan of irg-7(zc6) mutants (Mantel-Cox, P = 0.53). (B) The irg-7(zc6) gof mutation improved the survival of animals fed with pathogenic HB bacteria (Mantel-Cox, P<0.0001). (C-D) irg-7 inactivation by pre-treatment with F40F4.6 RNAi from eggs to early adulthood hindered survival of animals fed henceforth with pathogenic HB bacteria (C) (Mantel-Cox, P<0.0001), but did not affect the survival of animals fed henceforth with OP50 bacteria (D) (Mantel-Cox, P = 0.7). (E) irg-7 inactivation by pre-treatment with F40F4.6 RNAi from eggs to early adulthood did not affect the survival of daf-16(mu86) mutants fed henceforth with HB bacteria (Mantel-Cox, P = 0.43). Mean lifespan are indicated within each graph. See S3 Table for additional lifespan data.

Fig 3

doi: https://doi.org/10.1371/journal.pgen.1006577.g003