Advertisement

< Back to Article

Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies

Table 2

Predicted and observed number of genome-wide-significant hits and PGS R2, for large-scale GWAS efforts to date for height, BMI, EduYears, and self-rated health, assuming 250k effective SNPs (i.e., independent haplotype blocks) of which 20k trait-affecting, using averaged GREML estimates from Table 1 for setting SNP heritability and CGR.

Notes on the sources for the large-scale GWAS efforts are listed in S3 Table.

Table 2

doi: https://doi.org/10.1371/journal.pgen.1006495.t002