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Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies

Fig 4

Theoretical predictions of out-of-sample R2 of the PGS, for the SNP heritability in the hold-out sample (x-axis) and the SNP heritability in the discovery samples (y-axis).

Factor levels: 50 studies, sample size 5,000 individuals per study, cross-study genetic correlation 0.8, 100k independent SNPs, and heritability arising from a subset of 1k independent SNPs.

Fig 4

doi: https://doi.org/10.1371/journal.pgen.1006495.g004