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Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies

Fig 3

Theoretical predictions of power per causal SNP (upper panel) and out-of-sample R2 of the PGS (lower panel), for a trait with GWAS results from the number of studies (x-axis) with cross-study genetic correlation (y-axis).

Factor levels: total sample size 250,000 individuals, 100k independent SNPs, and arising from a subset of 1k independent SNPs.

Fig 3

doi: https://doi.org/10.1371/journal.pgen.1006495.g003