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Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies

Fig 2

Theoretical predictions of power per causal SNP (upper panel) and out-of-sample R2 of the PGS (lower panel), for a trait that across studies has SNP heritability (x-axis) and cross-study genetic correlation (y-axis).

Factor levels: 50 studies, sample size 5,000 individuals per study, 100k independent SNPs, and heritability arising from a subset of 1k independent SNPs.

Fig 2