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Gene co-expression network connectivity is an important determinant of selective constraint

Fig 1

Population location and gene expression overview.

(A) Map of the original locations of the SwAsp populations. The red arrow points to the location of the common garden used in this study. (B) Distribution of gene expression heritability for all genes and for the subset of genes after filtering to remove uninformative expression. (C) Distribution of gene expression QST for all genes and for the subset of genes after filtering to remove uninformative expression. (D) Sample clustering based on all samples, including biological replicates. The heatmap represents the sample correlation matrix based on the 500 genes with the highest expression variance using gene expression data prior to hidden confounder removal. Darker colour indicates higher correlation. The coloured bar represents the populations the samples belong to. The small clusters on the diagonal correspond to biological replicates of each genotype.

Fig 1

doi: https://doi.org/10.1371/journal.pgen.1006402.g001