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Widespread Shortening of 3’ Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection

Fig 6

Tandem 3’ UTR shortening allows evasion of regulation by miRNAs.

(A) Distribution of frequency of miRNA target sites per nucleotide in the extended regions of Tandem UTRs that either show no change after infection (grey) or significantly change after infection (blue). (B) Significantly enriched miRNA target sites (FDR ≤ 10%, |FC| > 1.5) in the extended regions of significantly changing Tandem UTRs after infection with Listeria-only (top), with Salmonella-only (middle), or both bacteria (bottom). For each bacteria, the barplots in the left panels show the fold enrichment (x-axis, log2 scale) of target sites in the extended regions. White bars represent non-significant enrichments. Panels on the right show the fold change in miRNA expression (x-axis, log2 scale with standard error bars) after either 2 hours of infection (light colors) or 24 hours of infection (dark colors).

Fig 6