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Widespread Shortening of 3’ Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection

Fig 5

Relationship between RNA processing changes and gene expression changes.

(A) Distribution of fold changes in gene expression (y-axis, log2 scale) for genes with significant skipped exon changes after infection (purple) and genes with no change after infection (gray). (B) Distribution of Spearman correlations between ΔΨ and fold change in gene expression across 60 individuals per gene (solid line), for genes with only one annotated alternative event and significantly changed SE usage (purple; nL = 46 genes and nS = 97 genes) or tandem UTR usage (blue; nL = 36 genes and nS = 86 genes). Dotted lines show distribution of the correlation coefficients after permuting ΔΨ values.

Fig 5

doi: https://doi.org/10.1371/journal.pgen.1006338.g005