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Widespread Shortening of 3’ Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection

Fig 1

Gene expression and isoform proportion differences in response to bacterial infection.

(A) Principal component analysis of gene expression data from all samples (PC1 and PC2 on the x- and y-axis, respectively). (B) IL24, a gene with significant changes in isoform usage upon infection with Listeria and Salmonella. For each IL24 isoform in response to infection, plotted are the average relative isoform usages across samples (left panel, top) with their isoform structures (left panel, bottom) and corresponding fold changes (right panel; log2 scale; with standard error bars). Isoforms are ordered by relative abundance in non-infected samples, and colored circles (right panel) correspond to colors in barplot (left panel). (C) Number of genes showing only DIU, only DGE, and both DIU and DGE upon infection with Listeria and Salmonella, (11,353 genes tested).

Fig 1

doi: https://doi.org/10.1371/journal.pgen.1006338.g001