Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy
A. Correlation between selection signals (iHS) and coronary artery disease (CAD) log odds genetic risk (ln(OR)), both represented as absolute values. Red line/upper right value, β from mixed effects regression. B. Base pair positional comparison of selection signals and CAD genetic risk across PHACTR1. Blue points, CAD log odds values; grey-orange or non-significant-significant points, iHS scores. Horizontal bar shows PHACTR1 gene (and intron) spans and location of index SNP if present. C. LD plots, r2. Populations: CEU, Utah residents with ancestry from northern and western Europe from the CEPH collection; GIH, Gujarati Indians in Houston, TX, USA.