A Genomic Map of the Effects of Linked Selection in Drosophila
Fig 4
The contribution of background selection and classic sweeps to scaled diversity levels around non-synonymous and synonymous substitutions.
(A) Observed and predicted scaled diversity levels around non-synonymous (left) and synonymous (right) substitutions. The predictions are based on the joint model for background selection and classic sweeps. (B) The contribution of background selection (blue) and classic sweeps (red) measured in terms of the coalescent rates that they induce. The rates are measured in units of 1/2Ne, where Ne is our estimate of the effective population size in the absence of linked selection. To make these graphs comparable to the scaled diversity levels in (A), with lower rates corresponding to higher scaled diversity levels, the direction of the y-axis is reversed. (C) The density of exonic sites (blue) and non-synonymous substitutions (red) as a function of distance from non-synonymous and synonymous substitutions. Densities are normalized by the average densities at distance >0.06cM; the shaded areas correspond to the use of a different linear scale.