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Animal Models Are Valid to Uncover Disease Mechanisms

Fig 1

Mice carrying a deletion syntenic to the human chromosome 16p11.2 (Sult1a1-Spn) exhibit multiple behavioral phenotypes associated with ASD.

Intriguingly, two of the key behavioral phenotypes (social interaction and social preference) of ASD are highly genetic-background–dependent.

doi: https://doi.org/10.1371/journal.pgen.1006013.g001