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Integrative Tissue-Specific Functional Annotations in the Human Genome Provide Novel Insights on Many Complex Traits and Improve Signal Prioritization in Genome Wide Association Studies

Fig 3

Case studies of MHC, ZRS, and hypomethylated TEs.

(a) GenoSkyline scores for seven tissues in the genomic region surrounding MYH6 and MYH7. (b) ESC-specific and fetal-cell-specific GS scores for the 5th intron of LMBR1. The red box marks the location of ZRS. (c) Bar plot of the mean GS scores for the 5th intron of LMBR1 and ZRS across nine tissue and cell types. (d) Boxplot of mean GS scores for four groups of hypomethylated TEs.

Fig 3