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3’UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells

Fig 3

miRNAs and genes enriched for conserved binding sites upstream to APA sites.

(A) Conserved and non-conserved miRNA binding sites for genes with APA site and at least 1000 3’ UTR bases around it are divided in different groups according to codon usage correlation. (B) Heat map representing the mean fold change (log2 scale) of each miRNA in the miRNA array experiment from the control (primary cells) sample. (C) Conserved binding sites around the APA site for miRNAs in the miR-17-92 cluster and for all miRNAs. Only genes with at least 1000 3’ UTR bases before and after the APA site were considered for the analysis. (D) Conserved binding sites upstream the long 3’UTR end for miRNAs in the miR-17-92 cluster and for all miRNAs. Only genes with at least 1000 bases 5’ to the long 3’UTR and with APA site were considered for the analysis. * indicates p-value<0.05 for the difference between conserved miRNA binding sites between Pro-Diff. and Pro-Prolif. Genes (A), or between all miRNAs and miRNAs from the miR-17-92 cluster (C,D).

Fig 3

doi: https://doi.org/10.1371/journal.pgen.1005879.g003